Clastogenicity of Quinoline Derivatives in the Liver Micronucleus Assay Using Rats and Mice
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概要
- 論文の詳細を見る
Induction of micronucleated liver cells (MN-liver cells) was examined with the hepatocarcinogenic quinoline and its fluorinated derivatives, 3-fluoroquinoline (3-FQ) and 5-fluoroquinoline (5-FQ), using non-hepatectomized rats and mice. Male F344 rats or ICR mice were given each test chemical at a daily dose of 0.5mmol/kg for three consecutive days by i.p. injection, and sacrificed at six or eleven days after the final treatment. The data may suggest that the induction frequencies of MN-liver cells by the quinoline derivatives correlate with the magnitudes of both their medium-term carcinogenicity and bacterial mutagenicity. Thus, the potently hepatocarcinogenic/mutagenic 5-FQ caused significantly higher levels of induction of MN-liver cells than the vehicle in both rats and mice. The non-hepatocarcinogenic/non-mutagenic 3-FQ showed no appreciable differences in MN-liver cell induction from the control group in rats and mice. Quinoline showed a slight and statistically insignificant increase of MN-liver cells in mice, but there was not such increase in rats. These findings may suggest the utility of the micronucleus test using hepatocytes from non-hepatectomized animals, although its sensitivity may be low as compared with hepatectomized animals.
- 社団法人日本薬学会の論文
- 2007-08-01
著者
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Kadoi Minoru
名古屋市立大学 薬
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Kadoi Minoru
Graduate School Of Pharmaceutical Sciences Nagoya City University
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Kadoi Minoru
エーザイ薬理安全性研究所
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Saeki Ken-ichi
エーザイ
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Saeki K
Graduate School Of Pharmaceutical Sciences Nagoya City University
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Saeki Ken-ichi
名古屋市立大学 薬
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Saeki Kenichi
Graduate School Of Pharmaceutical Sciences Nagoya City University
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Saeki Ken-ichi
Graduate School Of Pharmaceutical Sciences Nagoya City University
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Saeki Ken-ichi
Faculty Of Pharmaceutical Sciences Nagoya City University
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Saeki Ken-ichi
エーザイ薬理安全性研究所
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Hakura Atsushi
Drug Safety Research Laboratories, Eisai Co., Ltd.
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Suzuki Takayoshi
Division of Cellular and Gene Therapy Products, National Institute of Health Sciences
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Sofuni Toshio
Division Of Genetics And Mutagenesis:division Of Cellular And Gene Therapy Products National Institu
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Hakura Atsushi
Drug Safety Research Laboratories Eisai Co. Ltd.
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Hakura Atsushi
Drug Safety Research Laboratories Eisai Co. Ltb.
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Suzuki Takayoshi
Div. Of Cellular And Gene Therapy Products National Inst. Of Health Sciences
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Suzuki Takayoshi
Division Of Cellular & Gene Therapy Products National Institute Of Health Sciences
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Saeki Ken-ichi
Graduate School Of Pharmaceutical Sciences Nagoya City Univ.
関連論文
- Modification of the Carcinogenic Potency of Quinoline, a Hepatocarcinogen, by Fluorine Atom Substitution : Evaluation of Carcinogenicity by a Medium-Term Assay
- Clastogenicity of Quinoline Derivatives in the Liver Micronucleus Assay Using Rats and Mice
- Clastogenicity of Quinoline and Monofluorinated Quinolines in Chinese Hamster Lung Cells
- Activation of the Human Ah Receptor by Aza-Polycyclic Aromatic Hydrocarbons and Their Halogenated Derivatives
- Activation of the Aryl Hydrocarbon Receptor by Methyl Yellow and Related Congeners : Structure-Activity Relationships in Halogenated Derivatives
- Fluorinated Benzo[h]quinolines and Benzo[f]quinolines
- Clastogenicity of Quinoline Derivatives Tested by Micronucleus Induction in Vivo in the Hepatocytes of Partially Hepatectomized Mice
- P-15 Investigational study for hepatotoxicity in rats by E2011 repeated administration. 2) Bioactivation of benzothiazoles with amine structures in the Ames mutagenicity assay.(Proceedings of the 27th Annual Meeting)
- Gene expression profiles of hepatotoxin-treated human hepatocytes can be used to cluster unknown compounds according to their mode of action(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
- Cytochrome P450 2E1/2A6-Selective Inhibition by Halogenated Anilines on Metabolic Activation of Dimethylnitrosamine in Human Liver Microsomes