Microcystin-LR is not Mutagenic in vivo in the λ/lacZ Transgenic Mouse (Muta^<TM> Mouse)
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概要
- 論文の詳細を見る
The water pollution of toxic cyanobacteria (blue-green algae) is causing a serious public health problem in many parts of the world. Microcystin-LR (MCLR) is a potent cyclic heptapeptidic hepatotoxin produced by the cyanobacterium Microcystis aeruginosa. MCLR presents acute and chronic hazards to human health and has been linked to primary liver cancer in humans chronically exposed to this peptide toxin through drinking water. To assess the in vivo mutagenecity of MCLR, the λ/lacZ transgenie mice (Muta^<TM>Mouse) were treated with MCLR (1mg/kg per week × 4) and examined for mutant frequencies (MFs) in the lacZ and cll genes of liver and lungs. Micronucleus induction in peripheral blood cells was also assessed. Co-mutagenic effect of MCLR was studied in combination with N-nitrosodiethylamine (DEN). MCLR did not increase either MFs of the target genes in liver and lungs or micronucleus frequency in the peripheral blood cells of the λ/lacZ transgenic mouse. While DEN treatment increased MFs significantly, the co-administration of MCLR did not potentiate its mutagenicity. We conclude that pure MCLR has no in vivo mutagenicity as it failed to induce gene mutation and micronucleus in transgenic mouse. Its tumor promoting effect is independent of its interaction to DNA.
- 日本環境変異原学会の論文
- 2006-05-31
著者
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榊原 俊郎
北大理
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鈴木 孝
Graduate School Of Engineering Science Osaka University
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高柳 滋
北海道教育大学教育学部札幌
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鈴木 孝
金材技研
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HONMA Masamitsu
Natl. Inst. Health Sci.
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SAKON Takuo
Department of Mechanical Engineering, Faculty of Engineering and Resource Science, Akita University
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Takagi S
Department Of Quantum Matter Graduate School Of Advanced Sciences Of Matter Hiroshima University
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Tsutsui Satoshi
Japan Synchrotron Radiation Research Institute Spring-8
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鈴木 直
大阪大学大学院基礎工学研究科
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榊原 俊雄
東大物性研
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Suzuki Takayoshi
Division of Cellular and Gene Therapy Products, National Institute of Health Sciences
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Hayashi Makoto
Division of Genetics and Mutagenesis
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鈴木 孝
東北大 理
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Suzuki T
Fac. Of Engineering Kyushu Inst. Of Technol. Kitakyushu 804-8550 Jpn
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鈴木 考至
広大理
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HONMA Masamitsu
Division of Genetics and Mutagenesis, National Institute of Health Sciences
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Tsutsui Satoshi
Department Of Materials Science And Technology Iwate University
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Suzuki T
Issp University Of Tokyo
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Sasaki T
Center For Geo-environmental Science Faculty Of Engineering And Resource Science Akita University
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SUDA Toshimi
The Institute of Physical and Chemical Research
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Tatsuoka Sho
Graduate School Of Science Tokyo Metropolitan University
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Suzuki N
Riken (inst. Physical And Chemical Res.) Saitama
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Suzuki N
Osaka Univ. Osaka Jpn
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Suzuki Naoshi
Department Of Material Physics Osaka University
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Sugaya Takashi
Issp University Of Tokyo
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Susaki Tomofumi
Department Of Physics And Department Of Complexity Science And Engineering University Of Tokyo:(pres
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Sakon Takuo
Department Of Physics Faculty Of Science Tohoku University
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Shibata Tadashi
Department Of Physics Faculty Of Science Osaka University
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Suzuki T
Graduate School Of Science And Technology Chiba University
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Tsutsui Satoshi
Department Of Material Physics Faculty Of Engineering Science Osaka University
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Wang Li
National Safety Assessment Center of Traditional Chinese Medicine, West China Hospital, Sichuan Univ
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Suzuki N
Department Of Physical Science Graduate School Of Engineering Science Osaka University
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Suzuki Taira
Department Of Mterials Science And Technology Science University Of Tokyo
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Honma M
Division Of Genetics And Mutagenesis National Institute Of Health Sciences
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Wu De-sheng
West China School Of Public Health Sichuan University
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Hayashi Makoto
Division Of Cardiology Uwajima City Hospital
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Hayashi M
Division Of Genetics And Mutagenesis National Institute Of Health Sciences
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Zhan Li
National Chengdu Center for Safety Evaluation of Traditional Chinese Medicine, West China Hospital,
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Zhang Li-Shi
West China School of Public Health, Sichuan University
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Rajaguru Palanichamy
Division of Cellular and Gene Therapy Products, National Institute of Health Sciences
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Sasagawa Takao
Graduate School Of Frontier Sciences University Of Tokyo
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Sakakibara T
Department Of Electrical And Electronic Engineering Toyohashi University Of Technology
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Suzuki Takashi
Institute For Solid State Physics University Of Tokyo
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Zhan Li
National Chengdu Center For Safety Evaluation Of Traditional Chinese Medicine West China Hospital Si
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Honma Masamitsu
Division Of Genetics And Mutagenesis National Institute Of Health Science
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Rajaguru Palanichamy
Division Of Cellular And Gene Therapy Products National Institute Of Health Sciences:department Of B
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Shima Tatsushi
Rcnp Osaka University
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Suzuki Takayoshi
Division Of Cellular & Gene Therapy Products National Institute Of Health Sciences
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Saito Takashi
Institute For Chemical Research Kyoto University
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Tsutsui Satoshi
Research And Utilization Division Spring-8 Jasri
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Wang Li
National Chengdu Center For Safety Evaluation Of Traditional Chinese Medicine West China Hospital Si
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Suzuki Naoshi
Division Of Materials Physics Department Of Physical Science Graduate School Of Engineering Science Osaka University
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SUZUKI Takashi
Department of Applied Physics Faculty of Engineering, Nagoya University
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