The Mutagenic Activity of the Crude Extract Obtained from Silicon Dioxide and Titanium Dioxide with Pyrene and Sodium Chloride under Xenon Lamp Irradiation
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概要
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The mutagenic activity of the crude extract obtained from the reaction mixture of pyrene and sodium chloride in the presence of 2 metallic oxides [silicon dioxide : silicic anhydride form (SiO_2) and titanium dioxide : anatase form (TiO_2)] under xenon lamp irradiation was examined using Salmonella typhimurium tester strains (TA98 and TA100), and was compared with the mutagenic activity of 1-chloropyrene (1-CP), dichloropyrenes (DCP), 1-nitropyrene (1-NP) and dinitropyrenes (DNP) in the crude extract. In the presence of SiO_2,the mutagenicity of 1-NP in the crude extract, and that of the crude extract increased with the progress of the irradiation time. Moreover, the crude extract and 1-NP levels of mutagenicity were considerably similar in each exposure time. Accordingly, it was presumed that the increase of the mutagenic activity of the crude extract was caused by the increase of the yields of 1-NP in the crude extract. In the presence of TiO_2,the mutagenicity of 1-NP in the crude extract decreased for the extended irradiation time, but the mutagenicity of the crude extract increased in reverse. It was presumed that the increase of the mutagenic activity of the crude extract was due to increasing the yields of other strong mutagens other than 1-CP, DCP or 1-NP.
- 2000-06-01
著者
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杉山 英男
国立公衆衛生院
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Watanabe Tetsushi
Kyoto Pharmaceutical University
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杉山 英男
Dep. Of Environmental Health National Inst. Of Public Health
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HIRAYAMA TERUHISA
Kyoto Pharmaceutical University
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Sugiyama Hidetoshi
Kanagawa Environmental Research Center
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杉山 英男
公衆衛生院
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Sugiyama Hideo
Dep. Of Environmental Health National Inst. Of Public Health
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Hirayama Teruhisa
Kyoto College Of Pharmacy
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