Detection of Mutagenic 1-Chloro-3-, -6-, and -8-Nitropyrenes in Surface Soil Collected in Kyoto, Japan
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概要
- 論文の詳細を見る
Mutagenic 1-chloro-3-nitropyrene (1,3-CNP), 1,6-CNP and 1,8-CNP were detected in surface soil collected in Kyoto, Japan. First, 1,3-, 1,6- and 1,8-CNPs were synthesized by chlorination of 1-nitropyrene. Mutagenic activities obtained by Ames assay using Salmonella typhimurium strain TA98 under conditions without S9 mix were 1.22 revertants per nmol for 1,3-CNP, 1.14 for 1,6-CNP and 0.83 for 1,8-CNP. Miller's aryl hydrocarbon receptor (AhR) yeast reporter gene assay showed that the three CNPs had no AhR ligand activity. Surface soil was collected in Kyoto, Japan and analyzed for 1,3-, 1,6- and 1,8-CNPs by two-dimensional high-performance liquid chromatography with fluorescence detection and a zinc on-line catalytic column. 1,3-CNP, 1,6-CNP and 1,8-CNP were detected in the ranges 9.2-13.8, 3.4-4.6 and 4.3-5.0 pg per gram of soil (n=2), respectively.
- 公益社団法人日本薬学会の論文
- 2004-12-01
著者
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Hasei Tomohiro
京都薬科大学 公衆衛生学
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杉山 英男
国立公衆衛生院
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Hasei Tomohiro
Kyoto Pharmaceutical University
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Watanabe Tetsushi
Kyoto Pharmaceutical University
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杉山 英男
Dep. Of Environmental Health National Inst. Of Public Health
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HIRAYAMA TERUHISA
Kyoto Pharmaceutical University
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Hasei Tomohiro
Department of Public Health, Kyoto Pharmaceutical University
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MURAHASHI Tsuyoshi
Kyoto Pharmaceutical University
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Kawabata Mitokazu
Kyoto Pharmaceutical University
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Sugiyama Hidetoshi
Kanagawa Environmental Research Center
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杉山 英男
公衆衛生院
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Sugiyama Hideo
Dep. Of Environmental Health National Inst. Of Public Health
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Murahashi Tsuyoshi
Kyoto Pharmaceutical University:(present Office)nihon Pharmaceutical University
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Hirayama Teruhisa
Kyoto College Of Pharmacy
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