Influences of Polyaromatic Hydrocarbons and Heavy Metals on a Thyroid Carcinoma Cell Line
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the influences (cell toxicity, endocrine disrupting action, etc.) of polyaromatic hydrocarbons (PAHs) and heavy metals on the human thyroid gland by using a cultured thyroid cancer cell (8505C). Among the six PAHs tested (anthracene, benzo[a]anthracene, benzo[a]pyrene, benzo[k]fluoranthene, chrysene and pyrene), anthracene did not show any effect, but cell proliferation was enhanced by benzo[a]anthracene, benzo[a]pyrene and benzo[k]fluoranthene. Benzo[a]pyrene had an especially marked effect. On the other hand, cell toxicity was exhibited in four (cadmium, copper, nickel and zinc) of the twelve metals tested (aluminum, cadmium, calcium, copper, lead, magnesium, manganese, nickel, tin, zinc, selenate and selenite), and in particular, the influence of cadmium was remarkable. It was found that the toxicity of cadmium was decreased by the addition of high concentrations of either calcium or selenite.
- 公益社団法人日本薬学会の論文
- 2005-04-01
著者
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杉山 英男
国立保健医療科学院
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木津 良一
金沢大学薬学部
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木津 良一
同志社女子大学薬学部
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杉山 英男
国立公衆衛生院
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杉山 英男
Dep. Of Environmental Health National Inst. Of Public Health
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Sugiyama Hideo
Department Of Environmental Health National Institute Of Public Health
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Kobayashi J
Dep. Of Epidemiology And Environmental Health Juntendo Univ. School Of Medicine
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Kobayashi Jun
Laboratory Science, School of Health Science, Faculty of Medicine, Kanazawa University
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Kizu Ryoichi
Graduate School of Natural Science & Technology, Kanazawa University
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Sugiyama Hidetoshi
Kanagawa Environmental Research Center
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杉山 英男
公衆衛生院
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Kizu Ryoichi
金沢大学 自然科学研究科
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Kizu R
Faculty Of Pharmaceutical Sciences Kanazawa University
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Sugiyama Hideo
Dep. Of Environmental Health National Inst. Of Public Health
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