Studies on Metal-Catalyzed Hydrolyses of Clioquinol Conjugates in the Rabbit Body Following Intravenous Injection of Cu (II)-or Fe (III)-Gluconic Acid Complex System

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Metal-catalyzed hydrolyses of clioquinol-glucuronide (CG) and clioquinol-sulfate (CS) in the rabbit body were studied following intravenous injection of Cu (II)- or Fe (III)-gluconic acid complex system 6h after the oral administration of clioquinol (C). Molar fractions of C, CG and CS remained nearly constant through 24 h after administration of C at doses of 90-300mg/kg weight in rabbits which were not injected with Cu (II) or Fe (III). Therefore, molar fractions of C, CG and CS after the injection of Cu (II) or Fe (III) were monitored to clarify the metabolic changes of C. In rabbits injected with 2.5mg of Cu (II)/kg weight, C rapidly increased and CG and CS decreased after the injection of Cu (II). In rabbits injected with 20 mg of Fe (III)/kg weight, C and CS slowly increased and CG decreased until 18h after the injection of Fe (III). The patterns of the changes in molar fractions of C, CG and CS are consistent with the catalytic features of Cu (II) and Fe (III) seen in previous studies, and therefore, the changes in molar fractions of C, CG and CS observed in this study were considered to have been brought about as a result of metalcatalyzed hydrolyses of CG and CS or metal-catalyzed hydrolysis of CG in the rabbit body.
公益社団法人日本薬学会の論文
1984-08-25