Metal Complexes of D-Glucosamine and Its Derivatives. VIII. Metal Complexes of N-Methyl-D-glucosamine and Its Related Amino Sugars

概要

論文の詳細を見る
N-Methyl-D-glucosamine (I), D-glucosamine (II), D-galactosamine (III), D-man-nosamine (IV) and D-talosamine (V) were investigated by pH titration method on their complex formations with metal ions. The pK_a of these amino sugars were found to be I 7.86,II 7.38,III 7.61,IV 7.50,and V 7.98 respectively. Stability constants, log K_1 of seven I-metal complexes were in the order ; Cu 4.5>Pb 3.7>Zn 3.2>Ni 3.1>Cd 2.9≫Ca, Mg. Hydrolysis study on I-Cu complex revealed that I-Cu complex was more hydrolyzable to form monohydroxo complex I-Cu (OH), but less dimerized than II-Cu complex. Stability constants, log K_1 of the amino sugar-Cu complexes were measured ; II-Cu 4.8,III-Cu 4.6,IV-Cu 5.0 and V-Cu 5.7 respectively. Discussions are given on the complex formation of amino sugar with Cu^<2+> with conformational considerations.
社団法人日本薬学会の論文
1979-02-25