The presence of cytotoxic proteins in females of subfamily Arctiinae moths
スポンサーリンク
概要
- 論文の詳細を見る
Cytotoxic activity of aqueous extracts from adult moth abdomens of 12 species belonging to the subfamily Arctiinae was tested in vitro using human gastric carcinoma TMK-1 cells. The strong cytotoxic activity, down to a dilution of 1/105, was found in females of all of 12 species of moths. However, samples of the males of the same species were without cytotoxicity. Females of three species, not of this subfamily, and those of 9 species, belonging to other family than Arctiinae, did not show any cytotoxicity. The strong cytotoxic activity in female abdomens of Hyphantria cunea was located in the ovaries. The active principle in the extract sample from H. cunea was inactivated by heat, acid or alkaline treatment and digested by proteases, indicating probably protein in its nature. Thus, cytotoxic factors in moths of the subfamily Arctiinae were likely to be derived from their ovaries.
- 日本学士院の論文
著者
-
WAKABAYASHI Keiji
Cancer Prevention Division, National Cancer Center Research Institute
-
SUGIMURA Takashi
Cancer Prevention Basic Research Project, National Cancer Center Research Institute
-
Wakabayashi Keiji
Cancer Prevention Basic Research Project National Cancer Center Research Institute
-
WATANABE Masahiko
Cancer Prevention Division, National Cancer Center Research Institute
-
KOYAMA Kotaro
Cancer Prevention Division, National Cancer Center Research Institute
-
Sugimura Takashi
Cancer Prevention Basic Res. Project National Cancer Center Res. Inst.
-
Koyama K
National Cancer Center Res. Inst. Tokyo Jpn
-
Watanabe Masatoshi
Laboratory For Medical Engineering Division Of Materials Science And Chemical Engineering Graduate S
-
KOMATSU Toshitami
Hokkaido Goryokaku School for the Handicapped
-
SUGIMURA Takashi
Cancer Prevention Division, National Cancer Center Research Institute
-
KOYAMA Kotaro
Cancer Prevention Basic Research Project, National Cancer Center Research Institute
関連論文
- Detection of Initiating and Promoting Activity of Aminophenylnorharman with a Five-week In Vivo Initiation Assay
- Lack of a Dose-response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-Nitrosodiethylamine
- More Frequent β-Catenin Gene Mutations in Adenomas than in Aberrant Crypt Foci or Adenocarcinomas in the Large Intestines of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-treated Rats
- Development and Distribution of 2-Amino- 1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP)-induced Aberrant Crypt Foci in the Rat Large Intestine
- Epigenetic Regulation of the KAI1 Metastasis Suppressor Gene in Human Prostate Cancer Cell Lines
- Periodic analysis of urethane-induced pulmonary tumors in living A/J mice by respiration-gated X-ray microcomputed tomography
- Genetic polymorphisms of cyclooxygenase-2 and colorectal adenoma risk : The Self Defense Forces Health Study
- Rapid induction of replicating DNA synthesis in response to 2-amino-3, 4-dimethylimidazo[4, 5-f]quinoline in rat hepatocytes
- Inhibitory Effects of Diallyl Disulfide or Aspirin on 2-Amino-1-methyl-6-phenylimidazo [4,5-b] pyridine-induced Mammary Carcinogenesis in Rats
- Induction of multinucleated cells and apoptosis in the PC-3 prostate cancer cell line by low concentrations of polyethylene glycol 1000
- HETEROCYCLIC AMINES : MUTAGENS/CARCINOGENS PRODUCED DURING COOKING OF MEAT AND FISH
- Heterocyclic amines : Mutagens/carcinogens produced during cooking of meat and fish
- Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane
- Helicobacter pylori Extracts Exhibit Nicotinamide Adenine Dinucleotide-derived Adenylation but Not Mono(adenosine 5'-diphosphate-ribosyl)ation of DNA Ligase
- Efficient Method for Rapid Induction of Aberrant Crypt Foci in Rats with 2-Amino-1-methyl-6-phenylimidazo [4,5-b] pyridine
- Chemoprevention by Nimesulide, a Selective Cyclooxygenase-2 Inhibitor, of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine(PhIP)-induced Mammary Gland Carcinogenesis in Rats
- Possible Lack of Carcinogenic Potential of 9-(4’-Aminophenyl)-9H-pyrido[3,4-b]indole (aminophenylnorharman) for the Pancreatic Duct Epithelium in Hamsters
- O-18 Role of Human N-Acetyltransferase in the Metabolic Activation of 2-Phenylbenzotriazole (PBTA) Derivatives.(Proceedings of the 27th Annual Meeting)
- 21C-01-1 Metabolic Activation of PBTA-1 and PBTA-2 by Human Cytochrome P450 1A1.
- Randomized, double-blind, placebo-controlled trial of bovine lactoferrin in patients with chronic hepatitis C
- Occurrence of mutations in the epidermal growth factor receptor gene in X-ray-induced rat lung tumors
- Presence in Pieris rapae of Cytotoxic Activity against Human Carcinoma Cells
- PHYSIOLOGYCAL ROLE OF A APOPTOSIS-INDUCING PROTEIN, PIERISIN-1, IN CABBAGE BUTTERFLY, PIERIS RAPAE(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- Relationships between intestinal polyp formation and fatty acid levels in plasma, erythrocytes, and intestinal polyps in Min mice
- Inhibition by β-Carotene of Upper Respiratory Tumorigenesis in Hamsters Receiving Diethylnitrosamine Followed by Cigarette Smoke Exposure
- Purification of Pierisin, an Inducer of Apoptosis in Human Gastric Carcinoma Cells, from Cabbage Butterfly, Pieris rapae
- Anti-cancer Substance in Pieris brassicae
- Possible Lack of Carcinogenic Potential of 9-(4'-Aminophenyl)-9H-pyrido[3,4-b]indole (aminophenylnorharman) for the Pancreatic Duct Epithelium in Hamsters
- Detection of endogenous DNA adducts, O^6-carboxymethyl-2'-deoxyguanosine and 3-ethanesulfonic acid-2'-deoxycytidine, in the rat stomach after duodenal reflux
- Enzymatic Properties of Pierisin-1 and Its N-Terminal Domain, a Guanine-Specific ADP-Ribosyltransferase from the Cabbage Butterfly
- Esophageal anthracosis : Lesion mimicking malignant melanoma
- Detection and Cloning of a Protein Recognized by Anti-human Prostate-specific Antigen (PSA) Antibody in the Rat Ventral Prostate
- Suppression by Flavonoids of Cyclooxygenase-2 Promoter-dependent Transcriptional Activity in Colon Cancer Cells: Structure-Activity Relationship
- Effects of a Soybean Isoflavone Mixture on Carcinogenesis in Prostate and Seminal Vesicles of F344 Rats
- Suppression of Intestinal Polyp Development by Nimesulide, a Selective Cyclooxygenase-2 Inhibitor, in Min Mice
- Suppression of Nitric Oxide Production in Lipopolysaccharide-stimulated Macrophage Cells by ω3 Polyunsaturated Fatty Acids
- Granzyme B-positive primary gastric T-cell lymphoma : Gastric T-cell lymphoma with the possibility of extrathymic T cell origin
- Aberrant methylation of the vascular endothelial growth factor receptor-1 gene in prostate cancer
- 21WA-03-3 In Vivo Toxicity of Aminophenylnorharman, a Product from the Reaction of Norharman and Aniline, in F344 Rats.
- Intravascular large B-cell lymphoma presenting with mass lesions in the central nervous system : A report of five cases
- Malignant phyllodes tumor of the prostate: Retrospective review of specimens obtained by sequential transurethral resection
- Mycobacterium tuberculosis infection within Warthin's tumor : Report of two cases
- Imaging study of pancreatic ductal adenocarcinomas in Syrian hamsters using X-ray micro-computed tomography (CT)
- Mutagenic Specificity of N-Nitrosotaurocholic Acid in supF Shuttle Vector Plasmids
- Analysis of the Major RNA Adduct Derived from Aminophenylnorharman, a Novel Endogenous Mutagen and Carcinogen
- Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor, mofezolac
- Inhibition of intestinal carcinogenesis by a new flavone derivative, chafuroside, in oolong tea
- Cloning of Mongolian gerbil cDNAs encoding inflammatory proteins, and their expression in glandular stomach during H. pylori infection
- Dose-dependent suppression of hyperlipidemia and intestinal polyp formation in Min mice by pioglitazone, a PPARγ ligand
- Combined effects of prostaglandin E receptor subtype EP_1 and subtype EP_4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice
- Marked Enhancement by Fish Meal of Helicobacter pylori-induced Gastritis in Mongolian Gerbils
- Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents
- Detection of 3,3'-Dichlorobenzidine in Water from the Waka River in Wakayama, Japan
- Mutagenicity and Levels of 2-Phenylbenzotriazole (PBTA)-type Mutagens in Sewage Effluent, River Water, Sediment and Drinking Water Collected from the Yodo River System, Japan
- Mutagenicity of Surface Soils in Urban Areas of Aichi Prefecture, Japan, and Bangkok, Thailand
- Frequent Development of Murine T-Cell Lymphomas with TcRa/β^+, CD4^-/8^- Phenotype after Implantation of Human Inflammatory Breast Cancer Cells in BALB/c Nude Mice
- Pierisin-1 from cabbage butterfly suppresses HeLa tumor growth in nude mice
- In vitro Osteogenic Differentiation Potential of Dental Pulp Stem Cells
- Phylogenic distribution of poly(ADP-ribose) glycohydrolase and poly(ADP-ribose)-digesting phosphodiesterase
- Establishment of poly(ADP-ribose) polymerase-deficient mouse embryonic stem cell lines
- Cytotoxic phenanthroindolizidine alkaloids in Tylophora tanakae against human gastric carcinoma cells
- Pierisin-1 from cabbage butterfly suppresses HeLa tumor growth in nude mice
- The presence of cytotoxic proteins in females of subfamily Arctiinae moths
- Cytotoxic agent against human gastric carcinoma cells from a kind of Danaidae and its host plant
- Anti-cancer Substance in Pieris brassicae
- Persistence of pierisin-1 activities in the adult cabbage white butterfly, Pieris rapae, during storage after killing
- Increase of oxidant-related triglycerides and phosphatidylcholines in serum and small intestinal mucosa during development of intestinal polyp formation in Min mice
- Efficient transfection method using deacylated polyethylenimine-coated magnetic nanoparticles