Cytotoxic agent against human gastric carcinoma cells from a kind of Danaidae and its host plant

スポンサーリンク

概要

• 論文の詳細を見る

• Cytotoxic activity of chloroform-methanol extracts from 92 kinds of butterflies was tested in vitro against human gastric carcinoma TMK-1 cells. Among the species tested, cytotoxicity was found only in a kind of Danaidae, Ideopsis similis, with an IC50 value at the 5×1/106 dilution. The other butterflies showed no activity, even at a dilution of 1/102. Cytotoxic activity was also detected in chloroform-methanol extract from leaves of Tylophora tanakae, a food source for caterpillars of I. similis. The active principles in I. similis were thus suggested to be derived from compounds present in the leaves of T. tanakae.

• 日本学士院の論文

著者

• WAKABAYASHI Keiji

  Cancer Prevention Division, National Cancer Center Research Institute

• SUGIMURA Takashi

  Cancer Prevention Basic Research Project, National Cancer Center Research Institute

• Wakabayashi Keiji

  Cancer Prevention Basic Research Project National Cancer Center Research Institute

• WATANABE Masahiko

  Cancer Prevention Division, National Cancer Center Research Institute

• KOYAMA Kotaro

  Cancer Prevention Division, National Cancer Center Research Institute

• BABA Masaki

  Cancer Prevention Division, National Cancer Center Research Institute

• Sugimura Takashi

  Cancer Prevention Basic Res. Project National Cancer Center Res. Inst.

• Koyama K

  National Cancer Center Res. Inst. Tokyo Jpn

• Baba Masaki

  Cancer Prevention Division National Cancer Center Research Institute

• Watanabe Masatoshi

  Laboratory For Medical Engineering Division Of Materials Science And Chemical Engineering Graduate S

• TAKAHASHI Hiroaki

  Terumo Research and Development Center

• ISHIYAMA Haruo

  Terumo Research and Development Center

• KOYAMA Kotaro

  Cancer Prevention Basic Research Project, National Cancer Center Research Institute

• Ishiyama Haruo

  Terumo R & D Center

関連論文

• Detection of Initiating and Promoting Activity of Aminophenylnorharman with a Five-week In Vivo Initiation Assay
• Lack of a Dose-response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-Nitrosodiethylamine
• More Frequent β-Catenin Gene Mutations in Adenomas than in Aberrant Crypt Foci or Adenocarcinomas in the Large Intestines of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-treated Rats
• Development and Distribution of 2-Amino- 1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP)-induced Aberrant Crypt Foci in the Rat Large Intestine
• Epigenetic Regulation of the KAI1 Metastasis Suppressor Gene in Human Prostate Cancer Cell Lines
• Periodic analysis of urethane-induced pulmonary tumors in living A/J mice by respiration-gated X-ray microcomputed tomography
• Genetic polymorphisms of cyclooxygenase-2 and colorectal adenoma risk : The Self Defense Forces Health Study
• Rapid induction of replicating DNA synthesis in response to 2-amino-3, 4-dimethylimidazo[4, 5-f]quinoline in rat hepatocytes
• Inhibitory Effects of Diallyl Disulfide or Aspirin on 2-Amino-1-methyl-6-phenylimidazo [4,5-b] pyridine-induced Mammary Carcinogenesis in Rats
• Induction of multinucleated cells and apoptosis in the PC-3 prostate cancer cell line by low concentrations of polyethylene glycol 1000
• HETEROCYCLIC AMINES : MUTAGENS/CARCINOGENS PRODUCED DURING COOKING OF MEAT AND FISH
• Heterocyclic amines : Mutagens/carcinogens produced during cooking of meat and fish
• Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane
• Helicobacter pylori Extracts Exhibit Nicotinamide Adenine Dinucleotide-derived Adenylation but Not Mono(adenosine 5'-diphosphate-ribosyl)ation of DNA Ligase
• Efficient Method for Rapid Induction of Aberrant Crypt Foci in Rats with 2-Amino-1-methyl-6-phenylimidazo [4,5-b] pyridine
• VEGF-C and VEGF-A Synergistically Enhance Lymph Node Metastasis of Gastric Cancer(Molecular and Cell Biology)
• Chemoprevention by Nimesulide, a Selective Cyclooxygenase-2 Inhibitor, of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine(PhIP)-induced Mammary Gland Carcinogenesis in Rats
• The role of circulating IL-8 and VEGF protein in the progression of gastric cancer
• Urokinase-type plasminogen activator expression correlates with tumor angiogenesis and poor outcome in gastric cancer
• Pancreaticoduodenectomy for Perforated Gastric Malignant Lymphoma : Report of a Case
• Gastrojejunocolic Fistula After Gastrectomy with Billroth II Reconstruction : Report of a Case
• Effect of Combination Therapy with Matrix Metalloproteinase Inhibitor MMI-166 and Mitomycin C on the Growth and Liver Metastasis of Human Colon Cancer
• Urokinase Receptor and Vascular Endothelial Growth Factor Are Synergistically Associated with the Liver Metastasis of Colorectal Cancer
• Possible Lack of Carcinogenic Potential of 9-(4’-Aminophenyl)-9H-pyrido[3,4-b]indole (aminophenylnorharman) for the Pancreatic Duct Epithelium in Hamsters
• Optical diagnosis of gastric cancer using near-infrared multichannel Raman spectroscopy with a 1064-nm excitation wavelength
• Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors
• Immunohistochemical and genetic features of gastric and metastatic liver gastrointestinal stromal tumors : Sequential analyses
• Combination Therapy with Vascular Endothelial Growth Factor Neutralizing Antibody and Mitomycin C on Human Gastric Cancer Xenograft
• Therapeutic Effect of 1 M Tegafur-0.4 M 5-Chloro-2,4-dihydroxypyridine-1 M Potassium Oxonate (S-1) on Liver Metastasis of Xenotransplanted Human Colon Carcinoma
• Antitumor Effect of a Neutralizing Antibody to Vascular Endothelial Growth Factor on Liver Metastasis of Endocrine Neoplasm
• O-18 Role of Human N-Acetyltransferase in the Metabolic Activation of 2-Phenylbenzotriazole (PBTA) Derivatives.(Proceedings of the 27th Annual Meeting)
• 21C-01-1 Metabolic Activation of PBTA-1 and PBTA-2 by Human Cytochrome P450 1A1.
• Randomized, double-blind, placebo-controlled trial of bovine lactoferrin in patients with chronic hepatitis C
• Occurrence of mutations in the epidermal growth factor receptor gene in X-ray-induced rat lung tumors
• Presence in Pieris rapae of Cytotoxic Activity against Human Carcinoma Cells
• PHYSIOLOGYCAL ROLE OF A APOPTOSIS-INDUCING PROTEIN, PIERISIN-1, IN CABBAGE BUTTERFLY, PIERIS RAPAE(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
• Antitumor Effect on Human Gastric Cancer and Induction of Apoptosis by Vascular Endothelial Growth Factor Neutralizing Antibody
• Advanced Gastric Carcinoma in an 18-Year-Old Man: A Case Report
• Relationships between intestinal polyp formation and fatty acid levels in plasma, erythrocytes, and intestinal polyps in Min mice
• Inhibition by β-Carotene of Upper Respiratory Tumorigenesis in Hamsters Receiving Diethylnitrosamine Followed by Cigarette Smoke Exposure
• Purification of Pierisin, an Inducer of Apoptosis in Human Gastric Carcinoma Cells, from Cabbage Butterfly, Pieris rapae
• Anti-cancer Substance in Pieris brassicae
• Possible Lack of Carcinogenic Potential of 9-(4'-Aminophenyl)-9H-pyrido[3,4-b]indole (aminophenylnorharman) for the Pancreatic Duct Epithelium in Hamsters
• Detection of endogenous DNA adducts, O^6-carboxymethyl-2'-deoxyguanosine and 3-ethanesulfonic acid-2'-deoxycytidine, in the rat stomach after duodenal reflux
• Enzymatic Properties of Pierisin-1 and Its N-Terminal Domain, a Guanine-Specific ADP-Ribosyltransferase from the Cabbage Butterfly
• Esophageal anthracosis : Lesion mimicking malignant melanoma
• Detection and Cloning of a Protein Recognized by Anti-human Prostate-specific Antigen (PSA) Antibody in the Rat Ventral Prostate
• Suppression by Flavonoids of Cyclooxygenase-2 Promoter-dependent Transcriptional Activity in Colon Cancer Cells: Structure-Activity Relationship
• Effects of a Soybean Isoflavone Mixture on Carcinogenesis in Prostate and Seminal Vesicles of F344 Rats
• Suppression of Intestinal Polyp Development by Nimesulide, a Selective Cyclooxygenase-2 Inhibitor, in Min Mice
• Suppression of Nitric Oxide Production in Lipopolysaccharide-stimulated Macrophage Cells by ω3 Polyunsaturated Fatty Acids
• Crohn's Disease of the Esophagus : Report of a Case
• Granzyme B-positive primary gastric T-cell lymphoma : Gastric T-cell lymphoma with the possibility of extrathymic T cell origin
• Aberrant methylation of the vascular endothelial growth factor receptor-1 gene in prostate cancer
• 21WA-03-3 In Vivo Toxicity of Aminophenylnorharman, a Product from the Reaction of Norharman and Aniline, in F344 Rats.
• Intravascular large B-cell lymphoma presenting with mass lesions in the central nervous system : A report of five cases
• Malignant phyllodes tumor of the prostate: Retrospective review of specimens obtained by sequential transurethral resection
• Mycobacterium tuberculosis infection within Warthin's tumor : Report of two cases
• Imaging study of pancreatic ductal adenocarcinomas in Syrian hamsters using X-ray micro-computed tomography (CT)
• Mutagenic Specificity of N-Nitrosotaurocholic Acid in supF Shuttle Vector Plasmids
• Analysis of the Major RNA Adduct Derived from Aminophenylnorharman, a Novel Endogenous Mutagen and Carcinogen
• Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor, mofezolac
• Inhibition of intestinal carcinogenesis by a new flavone derivative, chafuroside, in oolong tea
• Cloning of Mongolian gerbil cDNAs encoding inflammatory proteins, and their expression in glandular stomach during H. pylori infection
• Dose-dependent suppression of hyperlipidemia and intestinal polyp formation in Min mice by pioglitazone, a PPARγ ligand
• Combined effects of prostaglandin E receptor subtype EP_1 and subtype EP_4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice
• Marked Enhancement by Fish Meal of Helicobacter pylori-induced Gastritis in Mongolian Gerbils
• Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents
• Detection of 3,3'-Dichlorobenzidine in Water from the Waka River in Wakayama, Japan
• Mutagenicity and Levels of 2-Phenylbenzotriazole (PBTA)-type Mutagens in Sewage Effluent, River Water, Sediment and Drinking Water Collected from the Yodo River System, Japan
• Mutagenicity of Surface Soils in Urban Areas of Aichi Prefecture, Japan, and Bangkok, Thailand
• Frequent Development of Murine T-Cell Lymphomas with TcRa/β^+, CD4^-/8^- Phenotype after Implantation of Human Inflammatory Breast Cancer Cells in BALB/c Nude Mice
• Pierisin-1 from cabbage butterfly suppresses HeLa tumor growth in nude mice
• TSU68, an Antiangiogenic Receptor Tyrosine Kinase Inhibitor, Induces Tumor Vascular Normalization in a Human Cancer Xenograft Nude Mouse Model
• In vitro Osteogenic Differentiation Potential of Dental Pulp Stem Cells
• Phylogenic distribution of poly(ADP-ribose) glycohydrolase and poly(ADP-ribose)-digesting phosphodiesterase
• Establishment of poly(ADP-ribose) polymerase-deficient mouse embryonic stem cell lines
• Cytotoxic phenanthroindolizidine alkaloids in Tylophora tanakae against human gastric carcinoma cells
• Pierisin-1 from cabbage butterfly suppresses HeLa tumor growth in nude mice
• The presence of cytotoxic proteins in females of subfamily Arctiinae moths
• Cytotoxic agent against human gastric carcinoma cells from a kind of Danaidae and its host plant
• Anti-cancer Substance in Pieris brassicae
• Antiangiogenic therapy for liver metastasis of gastrointestinal malignancies
• Microarray analysis identifies versican and CD9 as potent prognostic markers in gastric gastrointestinal stromal tumors
• Persistence of pierisin-1 activities in the adult cabbage white butterfly, Pieris rapae, during storage after killing
• Increase of oxidant-related triglycerides and phosphatidylcholines in serum and small intestinal mucosa during development of intestinal polyp formation in Min mice
• Efficient transfection method using deacylated polyethylenimine-coated magnetic nanoparticles
• Clinical and Experimental Studies on Apheresis and Development of a Bioartificial Liver in Fulminant Hepatic Failure(Symposium 2: Plasmapheresis and/or Transplant for Fukminant Hepatic Failure)

もっと見る 閉じる

スポンサーリンク