VEGF-C and VEGF-A Synergistically Enhance Lymph Node Metastasis of Gastric Cancer(Molecular and Cell Biology)
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概要
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Purpose: Vascular endothelial growth factor C (VEGF-C) is the most important molecule in lymphangiogenesis and its relationship with lymph node metastasis has attracted considerable interest. We investigated the relationship of VEGF-C or VEGF-A with clinicopathological factors in gastric cancer patients. Methods: Eighty gastric cancer patients who underwent gastric resection were analyzed immunohistochemically for expression of VEGF-C and VEGF-A protein. Results: Positive immunoreactivity of VEGF-C and VEGF-A was observed in 75 (93.8%) and 41,(51.3%) patients, respectively. VEGF-A expression was significantly correlated with tumor differentiation (p=0.0017) and vascular invasion (p=0.0004). And positive relationship of VEGF-C expression was only demonstrated with tumor differentiation (p=0.0168). Interestingly, however, the frequency of lymph node metastasis was significantly higher in the patients with expression of both VEGF-C and VEGF-A (strong positive expression,/;=0.036). Furthermore, the expression of both was also significantly correlated with depth of tumor invasion, tumor differentiation, lymphatic invasion, and vascular invasion. Conclusion: The present results suggest that strong expression of VEGF-A in addition to VEGF-C expression is essential in lymph node metastasis, presumably because enhanced metastatic potential including lymphangiogenesis induced by both VEGF-A and VEGF-C is vital in lymph node metastasis of gastric cancer.
- 2007-04-01
著者
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KONNO HIROYUKI
Second Department of Surgery, Hamamatsu University School of Medicine
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KONDO Kenji
Second Department of Surgery, Hamamatsu University School of Medicine
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KANEKO Takeshi
Second Department of Surgery, Hamamatsu University School of Medicine
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BABA Megumi
Second Department of Surgery, Hamamatsu University School of Medicine
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Konno Hiroyuki
Second Department Of Surgery Hamamatsu University School Of Medicine
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Konno Hiroyuki
浜松医科大学 第2外科
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Kaneko Takeshi
Second Department Of Surgery Hamamatsu University School Of Medicine
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KANAI TOSHIKAZU
Inasa Redcross Hospital
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Baba M
Second Department Of Surgery Hamamatsu University School Of Medicine
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Kamiya Kinji
Second Department Of Surgery Hamamatsu University School Of Medicine
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Kurachi Kiyotaka
Second Department Of Surgery Hamamatsu University School Of Medicine
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Baba Masaki
Cancer Prevention Division National Cancer Center Research Institute
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Kondo Kenji
Second Department Of Surgery Hamamatsu University School Of Medicine
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Baba Megumi
Second Department Of Surgery Hamamatsu University School Of Medicine
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Konno Hiroyuki
Matsuda Hospital
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Kamo Takaharu
Department Of Surgery Ii Hamamatsu University School Of Medicine
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