Lack of altered frequency of sister-chromatid exchanges in poly(ADP-ribose) glycohydrolase-deficient mouse ES cells treated with methylmethanesulfonate

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概要

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• Poly(ADP-ribose) glycohydrolase plays a central role in poly(ADP-ribose) degradation, cleaving α(ribose-ribose) bonds to produce ADP-ribose. We previously generated Parg-deficient (Parg+/- and Parg-/-) mouse embryonic stem (ES) cells by disrupting exon 1 of the Parg gene, and showed the Parg-/- ES cells to be hypersensitive to methylmethanesulfonate, an alkylating agent. To clarify the role of Parg in the maintenance of genomic stability, we examined the frequency of sister-chromatid exchanges (SCEs) in Parg+/+ and Parg-/- ES cells with and without methylmethanesulfonate treatment. No difference was observed in the spontaneous frequency of SCEs between the Parg genotypes, treatment with methyl-methanesulfonate at 50 μM causing approximately 2-fold elevation in both cases.(Contributed by Takashi SUGIMURA, M. J. A., Dec. 12, 2003)

• 日本学士院の論文

著者

• JISHAGE Kou-ichi

  Chugai Research Institute for Medical Science

• NAKAGAMA Hitoshi

  Biochemistry Division, National Cancer Center Research Institute

• Nakagama Hitoshi

  Biochemistry Division National Cancer Center Research Institute

• SUGIMURA Takashi

  Biochemistry Division, National Cancer Center Research Institute

• FUJIHARA Hisako

  Biochemistry Division, National Cancer Center Research Institute

• KAMADA Nobuo

  Chugai Pharmaceutical Co., Ltd.

• MASUTANI Mitsuko

  Biochemistry Division, National Cancer Center Research Institute

• Kamada N

  Chugai Pharmaceutical Co. Ltd. Shizuoka

• Kamada Nobuo

  Chugai Pharmaceutical Co. Ltd.

• OMURA Ken

  Department of Advanced Molecular Diagnosis and Maxillofacial Surgery, Graduate School, Tokyo Medical

• Fujihara Hisako

  Biochemistry Division National Cancer Center Research Institute

• Masutani Mitsuko

  Biochemistry Division National Cancer Center Research Institute

• GUNJI Akemi

  Biochemistry Division, National Cancer Center Research Institute

• Sugimura Takashi

  Biochemistry Division National Cancer Center

• Jishage Kou-ichi

  Chugai Res. Inst. For Medical Sci.

• OMURA Ken

  Department of Oral Surgery, Tokyo Medical and Dental University Graduate School

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