Production of Mice Entirely Derived from Embryonic Stem (ES) Cell with Many Passages by Coculture of ES Cells with Cytochalasin B Induced Tetraploid Embryos
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概要
- 論文の詳細を見る
Mice entirely derived from ES cells were obtained from aggregates of TT2 ES cells and cytochalasin B induced tetraploid embryos. Tetraploid embryos were cocultured with ES cells in a well on the Multiplate-Terasaki. After embryo transfer of the aggregates, the male newborns were recovered normally after Cesarean section and reached adulthood. The male mice exhibited complete pigmentation of the eye and coat, suggesting ES cell contributions alone. Alkaline phosphatase-1 analysis yielded no evidence of tetraploid cells in the kidney or liver. The TT2-derived males were fertile, produced normal offspring, and exclusively transmitted the TT2 genotype to their progeny. This result clearly shows that ES cells are able to support complete fetal development.
- 社団法人 日本実験動物学会の論文
著者
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Kamada N
Chugai Pharmaceutical Co. Ltd. Shizuoka
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UEDA Otoya
Laboratory of Molecular Genetics and Embryology, CSK Research Park Inc.
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UEDA Otoya
CSK Research Park Inc., Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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JISHAGE Kouichi
CSK Research Park Inc., Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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KAMADA Nobuo
CSK Research Park Inc., Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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UCHIDA Satomi
CSK Research Park Inc., Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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SUZUKI Hiroshi
CSK Research Park Inc., Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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Uchida S
Csk Research Park Inc. Fuji Gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.
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Jishage K
Laboratory Of Molecular Genetics And Embryology Csk Research Park Inc.
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Ueda Otoya
Laboratory Of Molecular Genetics And Embryology Csk Research Park Inc.
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Ueda O
Fuji-gotemba Research Laboratories Chugai Pharmaceutical Co.
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Sano Hiroyuki
Chugai Pharmaceutical Co. Ltd.
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Uchida Satomi
Csk Research Park Inc. Fuji Gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.
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Suzuki H
National Research Center For Protozoan Diseases Obihiro University Of Agriculture And Veterinary Med
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UEDA Otoya
CSK Research Park Inc.
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KAMADA Nobuo
CSK Research Park Inc.
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