Hyaluronan-based Biomaterials in Tissue Engineering(Prof. K Watanabe Memorial Article)

概要

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There has been an increasing interest in reabsorbed or degradable biomaterials with hyaluronan (HA)-based high molecular polymers in tissue engineering techniques, where scaffold biomaterials are used as a career matrix, and materials of culture cells or three-dimensional tissue reconstruction. Clinical application of biopolymers has been described using different molecular engineering strategies involving a variety of biosynthetic and modified natural polymers like ECM molecules including hyaluronan and glucosaminoglycans. The present report attempts to evaluate HA-based biomaterials as reconstructive or augmentation materials for repair tissue loss or great tissue damage. Excellent histocompatibility and biodegradability in HA-based biomaterials as HYAFF^[○!R] are achieved in cases of synthetic bioskin and biosynthetic osteo-cartilage tissues for tissue reconstruction. A variety of growth factors and cytokines have also served to promote cell migration, proliferation and new tissue formation onto biomaterials.
日本組織細胞化学会の論文