Evaluation of the Observed Cisplatin Nephrotoxicity in Adult Cancer Inpatients : A Historical Cohort Study by Using Clinical Data Warehouse
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概要
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Objectives: To evaluate the observed cisplatin (CDDP) nephrotoxicity in adult cancer inpatients by using Clinical Data Warehouse (CDW). Methods: A historical cohort study was conducted in Osaka University Hospital. Adult cancer inpatients (2000/1/1-2004/12/31) whose sCr level on admission < 1.2mg/dl were divided into three groups based on the exposure of CDDP, non-exposure of CDDP but with (Non-CDDP group) or without (Control group) other anticancer agents. Patients whose sCr ≥ 1.2mg/dl at least once during hospitalization were considered as those having the occurrence of the nephrotoxicity and their sCr < 1.2mg/dl on discharge as having recovered from the nephrotoxicity. After matching patients' characteristics through stratification and randomization, the rates of nephrotoxicity and the rates of recovery among the three groups were compared. Logistic regression was performed to investigate the CDDP doses-nephrotoxicity associations. Results: The rate of observed nephrotoxicity was 28.0% (127/454) in the CDDP group, 19.6% (89/454) in the Non-CDDP group and 19.4 % (88/454) in the Control group, respectively (p=0.002). The risk ratio (RR) was 1.43 (95%CI: 1.13-1.81), 1.44 (95%CI: 1.14-1.83) and 1.01 (95%CI: 0.78-1.41) between CDDP vs. Non-CDDP CDDP vs. the control and Non-CDDP vs. the Control group. The recovery rate was 69.3% (88/127), 61.8% (55/89) and 69.3% (61/88) in the three groups, respectively (p=0.903). The observed CDDP nephrotoxicity was dose associated (p=0.037) but not total accumulated doses associated (p=0.144). Conclusions: CDDP is a risk factor to the observed nephrotoxicity in our adult cancer inpatients. The observed nephrotoxicity was CDDP dose related and is considered to be reversible.
- 公益社団法人日本薬学会の論文
- 2006-04-01
著者
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TAKEDA Hiroshi
Department of Medical Information Science, Osaka University Graduate School of Medicine
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Matsumura Yasushi
Department of Cardiology, Osaka University School of Medicine
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Matsumura Yasushi
Department Of Cardiology Osaka University School Of Medicine
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Yoshimoto Sachiko
Department of Cardiology, Osaka National Hospital
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Yoshimoto Sachiko
Department Of Cardiology Osaka National Hospital
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Yoshimoto Sachiko
Department Of Integrated Medicine Medical Informatics Graduated School Of Medicine Osaka University
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Kuwata Shigeki
Medical Informatics Division Totori University Hospital
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Zhang Qiyan
Department of Integrated Medicine, Medical Informatics, Graduated School of Medicine, Osaka Universi
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Teratani Tadamasa
Department of Integrated Medicine, Medical Informatics, Graduated School of Medicine, Osaka Universi
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Mineno Takahiro
Department of Integrated Medicine, Medical Informatics, Graduated School of Medicine, Osaka Universi
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Nakagawa Katsuhiko
Department of Integrated Medicine, Medical Informatics, Graduated School of Medicine, Osaka Universi
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Nagahama Munetoshi
Department of Integrated Medicine, Medical Informatics, Graduated School of Medicine, Osaka Universi
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Takeda Hiroshi
Department Of Earth And Planetary Science The University Of Tokyo
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Matsumura Yasushi
Department Of Integrated Medicine Medical Informatics Graduated School Of Medicine Osaka University
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Zhang Qiyan
Department Of Integrated Medicine Medical Informatics Graduated School Of Medicine Osaka University
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Nakagawa Katsuhiko
Department Of Integrated Medicine Medical Informatics Graduated School Of Medicine Osaka University
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Nakagawa Katsuhiko
Department Of Applied Chemistry And Biotechnology Niihama National College Of Technology
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Takeda Hiroshi
Department Of Integrated Medicine Medical Informatics Graduated School Of Medicine Osaka University
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Takeda Hiroshi
Department Of Abdominal Surgery Tenri Hospital
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Nagahama Munetoshi
Department Of Integrated Medicine Medical Informatics Graduated School Of Medicine Osaka University
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Mineno Takahiro
Department Of Integrated Medicine Medical Informatics Graduated School Of Medicine Osaka University
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Teratani Tadamasa
Department Of Integrated Medicine Medical Informatics Graduated School Of Medicine Osaka University
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