Insulin Autoimmune Syndrome Caused by an Adhesive Skin Patch Containing Loxoprofen-Sodium
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概要
- 論文の詳細を見る
A 62-year-old woman complained of repeated hypoglycemic events. A 75g oral glucose tolerance test (75gOGTT) showed a marked increase in the plasma insulin level and impaired glucose tolerance. The patient exhibited a high titer of plasma anti-insulin autoantibodies. Her diagnosis was insulin autoimmune syndrome (IAS). Following the cessation of loxoprofen-sodium (LOXs), she experienced no further hypoglycemic episodes. However, the hypoglycemic attacks recurred following the accidental readministration of LOXs in an adhesive skin patch. Considering the changes in the titer of anti-insulin autoantibodies, the repeated 75gOGTT and the repeated Scatchard analysis, we determined LOXs to be the cause of the IAS and evaluated the characteristics of the autoantibodies.
- 社団法人 日本内科学会の論文
著者
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Yagi Kunimasa
Department Of Internal Medicine Kanazawa University Graduate School Of Medical Science
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Yoshimoto Sachiko
Department Of Cardiology Osaka National Hospital
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Takeda Yoshiyu
Department Of Internal Medicine Fukui Cardiovascular Center
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Wakasugi Takanobu
Department Of Cardiology
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Yamagishi Masakazu
Department of Advanced Electron Devices, The Institute of Scientific and Industrial Research (ISIR), Osaka University, Ibaraki, Osaka 567-0047, Japan
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Yoshimoto Sachiko
Department of Endocrinology and Metabolism, Komatsu Municipal Hospital, Japan
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Yagi Kunimasa
Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, Japan
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Okazaki-Sakai Satoko
Department of Endocrinology and Metabolism, Komatsu Municipal Hospital, Japan
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Takeda Yoshiyu
Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, Japan
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Wakasugi Takanobu
Department of Endocrinology and Metabolism, Fukui Prefectural Hospital, Japan
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