Difference in the risk factors for coronary, renal and other peripheral arteriosclerosis in heterozygous familial hypercholesterolemia

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概要

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• Background: The aim of the present study was to clarify the risk factors of several types of arteriosclerosis lesions in Japanese individuals with heterozygous familial hypercholesterolemia (FH): renal arteriosclerosis (RAS), abdominal aortic sclerosis (AOS), iliac arteriosclerosis (IAS) and coronary artery disease (CAD). Methods and Results: Coronary angiography (CAG) and abdominal aortic angiography (AAA) were performed in 117 consecutive heterozygous FH subjects (79 men, 38 women; age 22-76). RAS (stenotic lesion or aneurysm) was observed in 39 cases (33%), predominantly in the proximal portion (74%) and both sides equally (right/left=27/23). Most cases of RAS (64%) presented with <25% stenosis. The differences in the contributing risk factors for the progression and development of RAS, AOS, IAS and CAD in FH were then analyzed. Multiple logistic regression analyses showed independent risk factors for formation of atherosclerosis in each artery were: age alone for RAS; age and plasma low-density lipoprotein cholesterol (LDL-C) for AOS; age, LDL-C and high-density lipoprotein cholesterol (HDL-C) for IAS; and HDL-C and diabetes mellitus for CAD. Conclusion: In Japanese subjects with heterozygous FH, there are distinct risk factors for the development and progression of atherosclerosis in the renal, iliac, abdominal aorta, and coronary arteries.

• 社団法人日本循環器学会の論文
• 2004-06-20

著者

• Shimizu Masami

  Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School

• Mabuchi Hiroshi

  Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School

• Shimizu Masami

  Cardiovascular Checkup Committee For School Pupils Of Kanazawa Medical Association

• Mizuno Sumio

  福井心臓血圧センター

• Mizuno Sumio

  金沢大学 循環器内科

• Inazu Akihiro

  Molecular Biochemistry And Molecular Biology Laboratory Kanazawa University Graduate School Of Medic

• Yagi Kunimasa

  Department of Internal Medicine, Kanazawa University Graduate School of Medical Science

• Yagi Kunimasa

  金沢大学 医学系研究科循環医科学専攻臓器機能制御学

• Yagi Kunimasa

  Department Of Internal Medicine Kanazawa University Graduate School Of Medical Science

• Yagi Kunimasa

  Department Of Internal Medicine Kanazawa University Hospital

• HIGASHIKATA Toshinori

  Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School

• Hifumi Senshu

  Department Of Internal Medicine Hokuriku Central Hospital

• Hifumi Senshu

  Division of Cardiology, Kanazawa Cardiovascular Hospital

• Mizuno Kiyo-o

  Division of Internal Medicine, Fukui Cardiovascular Hospital

• Nohara Atsushi

  Departments Of Lipidology Kanazawa University Graduate School Of Medical Science

• Koizumi Junji

  金沢大学 医学系研究科循環医科学専攻臓器機能制御学

• YAGI Kunimasa

  Molecular Genetics of Cardiovascular Disorders, Graduate School of Medical Science, Kanazawa Univers

• NOHARA Atsushi

  Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine (The Second Depa

• Hifumi Senshu

  Division Of Internal Medicine Hokuriku Central Hospital

• Uedsa Kousei

  Division Of Cardiology Komatsu Municipal Hospital

• Ueda Kosei

  Komatsu Municipal Hospital

• Umeda Ken

  Second Department Of Internal Medicine School Of Medicine Kanazawa University

• Mabuchi H

  Kanazawa Univ. School Of Medicine Kanazawa Jpn

• Yagi Kunimasa

  Division Of Cardiovascular Medicine Kanazawa University Graduate School Of Medicine

• Yagi Kunimasa

  Molecular Genetics Of Cardiovascular Disorders Graduate School Of Medical Science Kanazawa Universit

• Higashikata Toshinori

  Molecular Genetics Of Cardiovascular Disorders Division Of Cardiovascular Medicine Graduate School O

• Shimizu Masami

  Molecular Genetics Of Cardiovascular Disorders Division Of Cardiovascular Medicine Graduate School O

• Nohara Atushi

  Molecular Genetics of Cardiovascular Disorders, Graduate School of Medical Science, Kanazawa Univers

• Namura Masanobu

  Kanazawa Cardiovascular Hospital

• Kobayashi Junji

  Molecular Genetics of Cardiovascular Disorders, Graduate School of Medical Science, Kanazawa Univers

• Mizuno Kiyo-o

  Division Of Internal Medicine Fukui Cardiovascular Hospital

• Namura Masanobu

  Deparment Of Cardiology Kanazawa Cardiovascular Hospital

• Namura Masanobu

  2nd Department Of Internal Medicine Kanazawa University School Of Medicine

• Kobayashi Junji

  Departments Of Lipidology Kanazawa University Graduate School Of Medical Science

• Hifumi Senshu

  Division Of Cardiology Kanazawa Cardiovascular Hospital

• Mabuchi Hiroshi

  Molecular Genetics Of Cardiovascular Disorders Division Of Cardiovascular Medicine Graduate School O

• Hifumi Senshu

  2nd Department Of Internal Medicine Kanazawa University School Of Medicine

• Mizuno Kiyoo

  Division of Internal Medicine, Fukui Cardiovascular Hospital

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