Type III hyperlipoproteinemia exaggerated by Sheehan's syndrome with advanced systemic atherosclerosis - A 28-year clinical course

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概要

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• A 38-year-old Japanese woman was admitted to hospital for further examination of systemic xanthomas. She had a past history of genital bleeding during her third delivery at the age of 21 years. She was diagnosed with Sheehan's syndrome. Her serum total cholesterol and triglyceride concentrations were 500 and 898 mg/dl, respectively. She was also diagnosed as having type III hyperlipoproteinemia on the basis of the presence of a broad-β-band on agarose gel electrophoresis and extremely high concentrations of very-low-density lipoprotein cholesterol (310 mg/dl). The diagnosis was later confirmed by her apolipoprotein E isoforms (E2/E2) and genotypes (epsilon2/epsilon2). Thyroid and corticosteroid hormone replacement therapy cured the xanthomas, but also elevated her blood pressure. The serum concentration of intermediate-density lipoprotein cholesterol was consistently high, whereas that of low-density lipoprotein cholesterol was relatively low during the follow-up. Coronary atherosclerosis had already developed by the age of 38 years, and progressed significantly over the following 28 years. Severe stenotic lesions were observed in the bilateral renal arteries and carotid arteries, and in the abdominal aorta when she was 66 years old. These findings suggest that the continuous elevation of intermediate-density lipoprotein cholesterol for a long period contributed to the development of the atherosclerotic lesions.

• 社団法人日本循環器学会の論文
• 2005-05-20

著者

• Shimizu Masami

  Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School

• Mabuchi Hiroshi

  Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School

• Shimizu Masami

  Cardiovascular Checkup Committee For School Pupils Of Kanazawa Medical Association

• Mizuno Sumio

  福井心臓血圧センター

• Mizuno Sumio

  金沢大学 循環器内科

• Inazu Akihiro

  Molecular Biochemistry And Molecular Biology Laboratory Kanazawa University Graduate School Of Medic

• Shimizu Masami

  金沢大学 循環器内科

• Nohara Atsushi

  Department of Lipidology, Kanazawa University Graduate School of Medical Science

• Kobayashi Junji

  Department of Lipidology, Kanazawa University Graduate School of Medical Science

• Koizumi Junji

  Department of General Medicine, Kanazawa University Hospital

• Mabuchi H

  Departments Of Lipidology Kanazawa University Graduate School Of Medical Science

• Katoh Masahiko

  日本大学医学部附属駿河台病院 循環器科

• HIGASHIKATA Toshinori

  Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School

• Kitamura Masaru

  Department Of Radiology Kanazawa Cardiovascular Hospital

• Takata Mutsuko

  Division Of Cardiovascular Medicine Kanazawa University Graduate School Of Medical Science

• Takamura Masayuki

  Department Of Cardiology Kanazawa University

• Koizumi Junji

  Departments Of Lipidology Kanazawa University Graduate School Of Medical Science

• Nohara Atsushi

  Departments Of Lipidology Kanazawa University Graduate School Of Medical Science

• Miwa Kenji

  Division Of Cardiology Ishikawa Prefectural Hospital

• Koizumi Junji

  金沢大学 医学系研究科循環医科学専攻臓器機能制御学

• Inazu Akihiro

  School of Health Sciences, Faculty of Medicine, Kanazawa University

• Kawashiri Masaaki

  Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Disease

• Takata Mutsuko

  Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Disease

• Katsuda Shoji

  Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Disease

• Miwa Kenji

  Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Disease

• Katsuda Shoji

  Division Of Cardiology Graduate School Of Medical Science Kanazawa University

• Tsuchida Masayuki

  Division Of Cardiovascular Medicine Kanazawa University Graduate School Of Medical Science

• Mabuchi H

  Kanazawa Univ. School Of Medicine Kanazawa Jpn

• Koizumi Junji

  Department Of General Medicine Kanazawa University Graduate School Of Medical Science

• Higashikata Toshinori

  Molecular Genetics Of Cardiovascular Disorders Division Of Cardiovascular Medicine Graduate School O

• Shimizu Masami

  Molecular Genetics Of Cardiovascular Disorders Division Of Cardiovascular Medicine Graduate School O

• Kobayashi Junji

  Departments Of Lipidology Kanazawa University Graduate School Of Medical Science

• Shimizu Masami

  Second Department Of Internal Medicine School Of Medicine Kanazawa University

• Mabuchi Hiroshi

  Molecular Genetics Of Cardiovascular Disorders Vascular Medicine Division Of Cardiovascular Medicine

• Kobayashi Junji

  Department Of Chemistry Graduate School Of Science Osaka University

• Miwa Kenji

  Department Of Cardiology Ishikawa Prefectural Central Hospital

• Shimizu Masami

  The Second Department Of Internal Medicine School Of Medicine Kanazawa University

• Kawashiri Masaaki

  Division Of Cardiovascular Medicine Kanazawa University Graduate School Of Medical Science

• 間渕 博

  Departments Of Lipidology Kanazawa University Graduate School Of Medical Science

• Kitamura Masaru

  Division Of Cardiovascular Medicine Kanazawa University Graduate School Of Medical Science

• Nohara Atsushi

  Department Of Lipidology Kanazawa University Graduate School Of Medical Science

• Shimizu Masami

  The Second Department Of Internal Medicine School Of Medicine Kanazawa; University

• Mabuchi Hiroshi

  Molecular Genetics Of Cardiovascular Disorders Division Of Cardiovascular Medicine Graduate School O

• Shimizu Masami

  Department Of Internal Medicine Fukui Cardiovascular Center

• Shimizu Masami

  The Second Department Of Internal Medicine Kanazawa University Hospital

• Shimizu Masami

  Molecular Genetics Of Cardiovascular Disorders Division Of Cardiovascular Medicine Graduate School O

• Takamura Masayuki

  Department Of Internal Medicine Kanazawa University Graduate School Of Medical Sciences

• Mizuno Sumio

  Division Of Cardiology Fukui Cardiovascular Center Hospital

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