Increased Circulating Matrix Metalloproteinase-2 in Patients with Hypertrophic Cardiomyopathy with Systolic Dysfunction
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概要
- 論文の詳細を見る
Background: Some patients with hypertrophic cardiomyopathy (HCM) develop left ventricular (LV) wall thinning associated with LV dilatation and systolic dysfunction. Recently, matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPS) were reported to be involved in ventricular remodeling, however, little is known about MMPs and TIMPs in patients with HCM. Methods and Results: Enzyme-linked immunoassays were used to measure the plasma concentrations of MMP-2, MMP-3, MMP-9, TIMP-1, and TIMP-2 in 11 patients with HCM accompanied by systolic dysfunction (fractional shortening (FS) <25%, group A), 17 patients with HCM who had preserved systolic function (FS ≥25%, group B), and 50 age-matched clinically healthy control subjects (mean age: 57 years). The concentration of MMP-2 in group A was significantly higher than in group B and the control subjects (1,124±84, 792±49, 809+26 ng/ml, respectively), whereas there was no significant difference between group B and the control subjects. MMP-2 concentrations significantly increased as the New York Heart Association functional class increased in patients with HCM. TIMP-2 was also significantly higher in group A patients than in group B and the control subjects (45.3±4.7, 34.6±2.2, 33.7±1.8 ng/ml, respectively), but there was no difference between group B and control subjects. TIMP-1 was significantly higher in HCM patients than in control subjects. MMP-3 and MMP-9 concentrations did not differ among the 3 groups. Both MMP-2 and TIMP-2 correlated significantly with FS and LV dimension, negatively and positively, respectively. Conclusions: These results suggest that changes in the release and activity of MMP-2 and TIMP-2 may be associated with the mechanisms responsible for cardiac remodeling in patients with HCM.
- 社団法人日本循環器学会の論文
- 2004-03-20
著者
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Shimizu Kuniyoshi
The Second Department Of Internal Medicine School Of Medicine Kanazawa University
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Shimizu Kuniyoshi
Department Of Forest And Forest Products Sciences Faculty Of Agriculture Kyushu University
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Namura Masanobu
Department of Cardiology, Kanazawa Cardiovascular Hospital
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Ino Hidekazu
Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School
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Shimizu Masami
Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School
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Yamaguchi Masato
Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School
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Mabuchi Hiroshi
Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School
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Shimizu Masami
Cardiovascular Checkup Committee For School Pupils Of Kanazawa Medical Association
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Mizuno Sumio
福井心臓血圧センター
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Mizuno Sumio
金沢大学 循環器内科
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Shimizu Kuniyoshi
Department Of Internal Medicine Kouseiren Takaoka Hospital
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HIGASHIKATA Toshinori
Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School
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Nohara Atsushi
Departments Of Lipidology Kanazawa University Graduate School Of Medical Science
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NOJI Yoshihiro
Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine (The Second Depa
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NOHARA Atsushi
Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine (The Second Depa
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Noji Yoshihiro
Department Of Internal Medicine And Molecular Genetics Of Cardiovascular Disorders Division Of Cardi
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Mabuchi H
Kanazawa Univ. School Of Medicine Kanazawa Jpn
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Higashikata Toshinori
Molecular Genetics Of Cardiovascular Disorders Division Of Cardiovascular Medicine Graduate School O
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Shimizu Masami
Molecular Genetics Of Cardiovascular Disorders Division Of Cardiovascular Medicine Graduate School O
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ITO Yuji
Department of Bioengineering, Faculty of Engineering, Kagoshima University
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Matsuda Takeshi
Tsukuba Memorial Hospital
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Horita Takahiro
Department of Internal Medicine, Wajima Municipal Hospital
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Matsuda Takeshi
Matsuda Naika Clinic
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Ito Yuji
Department Of Internal Medicine Kkr Hokuriku Hospital
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Namura Masanobu
Deparment Of Cardiology Kanazawa Cardiovascular Hospital
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Namura Masanobu
2nd Department Of Internal Medicine Kanazawa University School Of Medicine
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Ito Yuji
Department Of Bioengineering Faculty Of Engineering Kagoshima University
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Shimizu Kuniyoshi
Depart. Of Internal Medicine Toyama Red Cross Hospital
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Yamagishi Masakazu
Molecular Genetics Of Cardiovascular Disorders Graduate School Of Medical Science Kanazawa Universit
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Itoh Hideki
Department Of Emergency And Critical Care Medicine Kanazawa University Hospital
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Inaba Hideo
Department Of Emergency And Critical Care Medicine Kanazawa University Hospital
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Mabuchi Hiroshi
Molecular Genetics Of Cardiovascular Disorders Division Of Cardiovascular Medicine Graduate School O
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Horita Takahiro
Department Of Internal Medicine Wajima Municipal Hospital
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Yamaguchi Masato
Molecular Genetics Of Cardiovascular Disorders Division Of Cardiovascular Medicine Graduate School O
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Ito Yuji
Department of Appleed Chemiaity and Bialownology,Facutory of Enginiaring,niigata Institute of Technology
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