Telmisartan treatment decreases Visceral Fat Accumulation and improves Serum Levels of Adiponectin and Vascular Inflammation Markers in Japanese Hypertensive Patients.
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概要
- 論文の詳細を見る
最終稿を登録可能.Hypertension contributes to the occurrence and progression of cardiovascular diseases. The angiotensin II type 1 receptor blocker telmisartan is reported to activate the peroxisome proliferator-activated receptor Υ and improve insulin sensitivity. We investigated the effects of telmisartan treatment on visceral fat, serum adiponectin and vascular inflammation markers in Japanese hypertensive patients. This was an open-label, non-controlled study. Twenty-eight essential hypertensive patients (22 men and 6 women; age 60.6±1.9 years; body mass index [BMI] 25.5±0.6 kg/m2) participated. Fat area was assessed with computerized tomography. All the subjects were started on telmisartan 40 mg/day, which was increased to 80 mg/day to achieve the blood pressure target of less than 130/80 mmHg. We assessed the visceral and subcutaneous fat areas, serum adiponectin levels, and vascular inflammation markers at baseline and 24 weeks of telmisartan treatment. There were significant reductions in visceral fat area (from 103.1±7.9 to 93.3±8.4 cm2, p<0.01) and pulse wave velocity (from 1,706±52 to 1,587±51 cm/s, p<0.01) at 24 weeks. In contrast, significant increases in serum high-density lipoprotein cholesterol (from 5.06±0.15 to 5.32±0.13 mmol/L, p<0.05) and adiponectin levels (from 8.27±0.76 to 9.13±0.81 pg/mL, p<0.05) were observed. Also, there were reductions in the interleukin-6 level (from 2.26±0.27 to 1.60±0.14 pg/mL, p<0.01). We also conducted these investigations in male subjects alone and similar findings were obtained for all of these parameters. In conclusion, telmisartan treatment was associated with an improvement of vascular inflammation, reductions in visceral fat and increases in serum adiponectin.
- 日本高血圧学会の論文
- 2007-12-01
著者
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MABUCHI Hiroshi
Department of Laboratory Science, Kanazawa University
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Mabuchi Hiroshi
Departments Of Lipidology Kanazawa University Graduate School Of Medical Science
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Mabuchi Hiroshi
金沢大学 医学系研究科循環医科学専攻
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Mabuchi Hiroshi
金沢大学 医学系研究科脂質研究
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Yamaguchi Masato
Division Of Cardiovascular Medicine Kanazawa University Graduate School Of Medical Science
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Yamagishi Masakazu
Department of Cardiology, National Cardiovascular Center
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Yamagishi Masakazu
Japanese Brugada Multicenter Registry By The Minister Of Health Labour And Welfare National Cardiova
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Kobayashi Junji
Department of Lipidology, Kanazawa University Graduate School of Medical Science
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Yagi Kunimasa
Department of Internal Medicine, Kanazawa University Graduate School of Medical Science
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Yagi Kunimasa
金沢大学 医学系研究科循環医科学専攻臓器機能制御学
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Yagi Kunimasa
Department Of Internal Medicine Kanazawa University Graduate School Of Medical Science
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Yagi Kunimasa
Department Of Internal Medicine Kanazawa University Hospital
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Mabuchi H
Departments Of Lipidology Kanazawa University Graduate School Of Medical Science
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Yamagishi Masakazu
Division Of Cardiovascular Medicine Kanazawa University Graduate School Of Medical Science
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CHUJO Daisuke
Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University
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ASANO Akimichi
Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University
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MURAMOTO Hiroaki
Kanazawa Social Insurance Hospital
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SAKAI Satoko
Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University
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OHNISHI Akitsu
Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University
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SHINTAKU KUBOTA
Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University
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Asano Akimich
Department Of Internal Medicine Kanazawa University Hospital
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Koizumi Junji
Departments Of Lipidology Kanazawa University Graduate School Of Medical Science
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Shintaku Kubota
Department Of Internal Medicine Graduate School Of Medical Science Kanazawa University
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Sakai Satoko
Department Of Internal Medicine Graduate School Of Medical Science Kanazawa University
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Koizumi Junji
金沢大学 医学系研究科循環医科学専攻臓器機能制御学
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Koizumi Junji
Department Of Lipidology Kanazawa University Graduate School Of Medicine
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Ohnishi Akitsu
Department Of Internal Medicine Graduate School Of Medical Science Kanazawa University
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Mabuchi Hiroshi
Department Of Internal Medicine And Molecular Genetics Of Cardiovascular Disorders Division Of Cardi
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Mabuchi H
Kanazawa Univ. School Of Medicine Kanazawa Jpn
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Chujo Daisuke
Department Of Internal Medicine Kanazawa University Hospital
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Yagi Kunimasa
Division Of Cardiovascular Medicine Kanazawa University Graduate School Of Medicine
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Kobayashi Junji
Departments Of Lipidology Kanazawa University Graduate School Of Medical Science
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Mabuchi Hiroshi
Molecular Genetics Of Cardiovascular Disorders Vascular Medicine Division Of Cardiovascular Medicine
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Kobayashi Junji
Department Of Chemistry Graduate School Of Science Osaka University
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Yamagishi Masakazu
Molecular Genetics Of Cardiovascular Disorders Graduate School Of Medical Science Kanazawa Universit
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間渕 博
Departments Of Lipidology Kanazawa University Graduate School Of Medical Science
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SAKAI S.
Department of Orthodontics, The University of Texas Health Science Center at San Antonio
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Mabuchi Hiroshi
Molecular Genetics Of Cardiovascular Disorders Graduate School Of Medical Science Kanazawa Universit
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Asano Akimichi
Department Of General Medicine Kanazawa University Hospital
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Sakai Satoko
Department Of Endocrinology And Metabolism Fukui Prefectural Hospital
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ASANO A.
Department of Pediatrics, Tokyo Medical College
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Ohnishi A.
Department Of Physics Faculty Of Scinence Hokkaido University
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Chujo D.
Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University
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Muramoto H.
Kanazawa Social Insurance Hospital
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Shintaku-Kubota M.
Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University
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Yamagishi Masakazu
Department of Advanced Electron Devices, The Institute of Scientific and Industrial Research (ISIR), Osaka University, Ibaraki, Osaka 567-0047, Japan
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YAMAGISHI Masakazu
Department of Advanced Electron Devices, The Institute of Scientific and Industrial Research (ISIR), Osaka University
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