Quantitative evaluation of the rate of myocardial interstitial fibrosis using a personal computer

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概要

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• We investigated the reliability and reproducibility of an image- analyzing system run on a personal computer for measurement of myocardial interstitial fibrosis. Measurements of myocardial interstitial fibrosis in right ventricular endomyocardial biopsies obtained from patients with hypertrophic cardiomyopathy determined by this image-analyzing system were compared with measurements determined by the point-counting method. We also investigated the correlation between measurements of interstitial fibrosis obtained by image analysis and biochemical measurements of myocardial levels of hydroxyproline in normal and cardiomyopathic hamsters. The intra- and interobserver variability were significantly lower for measurements obtained by the image-analyzing system than for measurements obtained by the point- counting system. Reproducibility was superior with the image-analyzing method. The rate of myocardial interstitial fibrosis determined by the computer image-analyzing method was positively correlated with the hydroxyproline measurement (r=0.89). Our results suggest that an image- analyzing system using a personal computer provides reproducible results with a high level of reliability.

• 社団法人日本循環器学会の論文
• 1997-08-20

著者

• Mabuchi Hiroshi

  Departments Of Lipidology Kanazawa University Graduate School Of Medical Science

• MABUCHI Hiroshi

  Second Department of Internal Medicine, Kanazawa University School of Medicine

• MATSUYAMA Toru

  Second Department of Internal Medicine, Kanazawa University Hospital

• Matsuyama Toru

  Molecular Genetics Of Cardiovascular Disorders Division Of Cardiovascular Medicine Graduate School O

• Kita Yoshihiro

  Fukui Cardiovascular center

• Matsuyama Toru

  Second Department Of Internal Medicine Kanazawa University Hospital

• Kita Yoshihito

  Second Department Of Internal Medicine School Of Medicine Kanazawa University

• SHIMIZU MASAMI

  Second Department of Internal Medicine, School of medicine, Kanazawa University

• Shimizu Masami

  Second Department Of Internal Medicine School Of Medicine Kanazawa University

• Yoshio Hiroyuki

  Second Department of Internal Medicine, School of Medicine, Kanazawa University

• Kitamura Masaru

  Second Department of Internal Medicine, School of Medicine, Kanazawa University

• Mabuchi Hiroshi

  Second Department Of Internal Medicine Kanazawa University School Of Medicine

• Ino Hidekazu

  Second Department of Internal Medicine, School of Medicine, Kanazawa University

• Misawa Katsushi

  Second Department of Internal Medicine, School of Medicine, Kanazawa University

• Kitamura Masaru

  Second Department Of Internal Medicine School Of Medicine Kanazawa University

• Misawa Katsushi

  Division Of Cardiovascular Medicine Kanazawa University Graduate School Of Medical Science

• Yoshio Hiroyuki

  Second Department Of Internal Medicine School Of Medicine Kanazawa University

• Yoshio Hiroyuki

  Department Of Internal Medicine Fukui Cardiovascular Center

• Mabuchi Hiroshi

  Second Department Of Internal Medicine Kanazawa University

• Kita Yoshito

  The Second Department Of Internal Medicine School Of Medicine Kanazawa University

• Yoshio Hiroyuki

  The Second Department Of Internal Medicine Kanazawa University School Of Medicine

• INO Hidekazu

  Second Department of Internal Medicine, School of Medicine, Kanagawa University

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