HISTOPATHOLOGICAL FACTORS RELATED TO DIASTOLIC FUNCTION IN MYOCARDIAL HYPERTROPHY
スポンサーリンク
概要
- 論文の詳細を見る
To clarify the histopathologic influence on diastolic function in the hypertrophied heart, we compared the echocardiographic and histopathologic findings in 9 controls, 10 patients with hypertrophic cardiomyopathy (HCM), and 8 hypertensive patients with asymmetric septal hypertrophy (HT-ASH). M-mode echocardiography was used to determine the left ventricular diastolic function. Mean diameter of myocytes, percentage of fibrosis and disarrangement were quantitatively calculated from right ventricular endomyocardial biopsy specimens. In both HT-ASH and HCM, the isovolumic relaxation time was significantly longer and the rapid filling volume tended to be smaller than in the controls. Histopathologically, the mean diameter of myocytes and percentage of myocardial interstitial fibrosis did not differ significantly between HT-ASH and HCM. However, quantitative disarrangement of myocytes in HCM was significantly greater than that in HT-ASH. Multiple regression analysis showed that the percentage of fibrosis was the most significant factor related to diastolic left ventricular dysfunction in HT-ASH, while disarrangement of myocytes was the most significant in HCM. We conclude that diastolic dysfunction in HT-ASH can be attributed to the percentage of fibrosis, and to disarrangement of myocytes in HCM.
- 社団法人日本循環器学会の論文
- 1992-04-20
著者
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TAKEDA Ryoyu
Department of Internal Medicine, Hokuriku Hospital
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Takeda Ryoyu
Department Of Internal Medicine Hokuriku Hospital
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Takeda Ryoyu
金沢大学 医学部内科学
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Takeda Ryoyu
高岡病院(厚生連)
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Ohsato Kazuo
Second Department Of Internal Medicine School Of Medicine Kanazawa University
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Takeda Ryoyu
Second Department Of Internal Medicine Kanazava University
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Takeda Ryoyu
Second Department Of Internal Medicine School Of Medicine Kanazawa University
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Takeda Ryoyu
The 2nd Department Of Internal Medicine Kanazawa University School Of Medicine
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Takeda Ryoyu
The Second Department Of Internal Medicine Kanazawa University School Of Medicine.
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SHIMIZU MASAMI
Second Department of Internal Medicine, School of medicine, Kanazawa University
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SUGIHARA NORIHIKO
Second Department of Internal Medicine, School of medicine, Kanazawa University
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KONJSHI KENSHO
Second Department of Internal Medicine, School of medicine, Kanazawa University
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Shimizu Masami
Second Department Of Internal Medicine School Of Medicine Kanazawa University
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SUGIHARA NORIHIKO
The Second Department of Internal Medicine, School of Medicine, Kanazawa University
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Konjshi Kensho
Second Department Of Internal Medicine School Of Medicine Kanazawa University
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Sugihara Norihiko
The Second Department Of Internal Medicine School Of Medicine Kanazawa University
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Takeda Ryoyu
The Second Department Of Internal Medicine School Of Medicine Kanazawa University
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Sugihara Norihiko
Second Department Of Internal Medicine School Of Medicine Kanazawa University
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Takeda Ryoyu
Department Of Internal Medicine Federation Of National Public Service Personnel Mutual Aid Associati
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Shimizu Masami
Molecular Genetics Of Cardiovascular Disorders Division Of Cardiovascular Medicine Graduate School O
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