Lecithin: Cholesterol Acyl Transfer Rate in Hypothyroidism and Hyperthyroidism

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概要

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• The initial rate of lecithin: cholesterol acyl transferase and serum concentration of lipids were determined in euthyroid, hypothyroid and hyperthyroid subjects.<BR>In hyperthyroid subjects, the serum levels of total and free cholesterol were significantly lower than in normal subjects and the fractional lecithin: cholesterol acyl transfer rate was significantly higher than in normal subjects. The molar lecithin: cholesterol acyl transfer rate was also higher than in normal subjects, but not significantly.<BR>The free cholesterol/total cholesterol ratio in hypothyroid females and the serum levels of triglyceride and free fatty acid in hypothyroid male were significantly higher than in normal subjects. The fractional lecithin: cholesterol acyl transfer rates in hypothyroid females were significantly lower than in normal females.<BR>After treatment of the thyroid disease the fractional and molar lecithin: cholestorol cholesterol acyl transfer rate approached the normal values. There was a positive correlation between fractional and molar lecithin: cholesterol acyl transfer rate and thyroxine.<BR>These results suggest that thyroid hormone influences the cholesterol esterification through the activation of lecithin: cholesterol acyltransferase.

• 社団法人 日本内分泌学会の論文

著者

• Takeda Ryoyu

  Second Department Of Internal Medicine Kanazava University

• Koizumi Junji

  Second Department of Internal Medicine, Kanazawa University

• Mabuchi Hiroshi

  Second Department Of Internal Medicine Kanazawa University School Of Medicine

• Kametani Tomio

  Department Of Internal Medicine Koseiren Takaoka Hospital

• KAMETANI TOMIO

  Second Department of Internal Medicine, University of Kanazawa School of Medicine

• HABA TOSHIHIRO

  Second Department of Internal Medicine, University of Kanazawa School of Medicine

• MIYAMOTO SUSUMU

  Second Department of Internal Medicine, University of Kanazawa School of Medicine

• KAWATO MASANORI

  Second Department of Internal Medicine, University of Kanazawa School of Medicine

• Mabuchi Hiroshi

  Second Department Of Internal Medicine Kanazawa University

• KOIZUMI JUNJI

  Second Department of Internal Medicine, University of Kanazawa School of Medicine

• TAKEDA RYOYU

  Second Department of Internal Medicine, University of Kanazawa School of Medicine

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