Pharmacokinetics of (-)Epicatechin 3-O-Gallate, Glycyrrhetic Acid and Rhein in Healthy Male Volunteers after Multiple Dose Administration of TJ-8117 (Unipito), a Japanese Traditional Medicine for Renal Failure
スポンサーリンク
概要
- 論文の詳細を見る
Aims: Unpito, an herbal medicine extracted from a mixture of five crude medicines (Rhei Rhizoma, Glycyrrhizae Radix, Ginseng Radix, Zingiberis Rhizoma and Aconiti Tuber), has been developed as a drug for chronic renal failure. In general, it is difficult to estimate the absorption and excretion of herbal medicines due to the presence of a wide variety of components. The purpose of the current study was to examine the systemic pharmacokinetics and elimination of Unpito in healthy volunteers following repeated administration as part of the clinical study of the medicine. Methods: Three compounds, (-) epicatechin 3-O-gallate (ECG), glycyrrhetic acid (GA) and rhein (RH) were selected as markers, to examine the clinical pharmacokinetics of Unpito based on their levels in this medicine. The disposition of each compound was evaluated in 24 healthy volunteers receiving multiple oral doses (4, 6, and 8 capsules three times a day). Results: After repeated administration, plasma ECG and GA concentrations were lower than those simulated. RH plasma concentrations were consistent with the simulation, indicating linear pharmacokinetics of RH. The potential accumulations of marker compounds were not observed from the roughly constant plasma concentrations of troughs at 72, 120, and 144 h after the first administration nor from the urinary excretions. Conclusions: This is the first study presenting pharmacokinetics of ECG, GA and RH derived from Unpito, an herbal medicine, in healthy volunteers after multiple dose administration.
- 日本臨床薬理学会 = The Japanese Society of Clinical Pharmacology and Therapeuticsの論文
- 2006-01-31
著者
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竹田 秀一
ツムラ研究本部
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Yamaguchi Takuji
ツムラ中央研究所
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油田 正樹
Res. Inst. Of Pharmaceutical Sciences Musashino Univ.
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油田 正樹
Medicinal Evaluation Laboratory Tsumura Research Institute
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Kase Y
Tsumura Research Laboratories Tsumura & Co.
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Kase Yoshio
ツムラ漢方生薬研究所
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Kase Yoshio
国立長寿医療センター研究所 老年病研究部
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Kase Yoshio
Central Research Laboratory Tsumura & Co.
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Aburada M
Fac. Of Pharmacy Musashino Univ.
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Aburada M
Tsumura Research Inst. Pharmacology Ibaraki Jpn
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加瀬 義夫
津村薬理研究所
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TAKIZAWA Yukiho
Pharmacology Research Department, Central Research Laboratories, R & D Division, Tsumura & Co.
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MIZUHARA Yasuharu
Pharmacology Research Department, Central Research Laboratories, R & D Division, Tsumura & Co.
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MORITA Toshimi
Pharmacology Research Department, Central Research Laboratories, R & D Division, Tsumura & Co.
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KASE Yoshio
Pharmacology Research Department, Central Research Laboratories, R & D Division, Tsumura & Co.
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TAKEDA Shuichi
Pharmacology Research Department, Central Research Laboratories, R & D Division, Tsumura & Co.
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ABURADA Masaki
Pharmacology Research Department, Central Research Laboratories, R & D Division, Tsumura & Co.
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Yuzurihara Mitsutoshi
Tsumura Research Laboratories Tsumura & Co.
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Yuzurihara Mitsutoshi
Central Research Laboratory Tsumura & Co.
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Yuzurihara Mitsutoshi
Kampo & Parmacognosy Laboratory Tsumura & Co.
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Miyamoto Ken-ichi
金沢大学 薬学部臨床薬物情報
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Miyamoto Ken-ichi
Dep. Of Clinical Pharmacy Graduate School Of Natural Sci. And Technol. Kanazawa Univ.
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Morota Takashi
Botanical Raw Materials Research Department Tsumura & Co.
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Morota Takashi
Botanical Raw Materials Research Dept. Tsumura & Co.
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Yanagisawa T
New Drug Discovery Laboratories R&d Division Tsumura & Co. Ltd.
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竹田 秀一
Tsumura & Co. Tsumura Res. Laboratories
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MIYAMOTO Ken-ichi
Hospital Pharmacy, School of Medicine Kanazawa University
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油田 正樹
ツムラ研究本部 医薬評価研究所
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Takizawa Yukiho
Medicinal Evaluation Laboratory Tsumura & Co.:department Of Medicinal Informatics Graduate Schoo
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Miyaamoto Ken-ichi
Department Of Medical Informatics Graduate School Of Medical Science Kanazawa University
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Mizuhara Yasuharu
Medicinal Evaluation Laboratory Tsumura & Co.:department Of Medicinal Informatics Graduate Schoo
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Yanagisawa Toshihiko
Tsumura&co.
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Yanagisawa Toshihiko
Central Research Laboratories Tsumura & Co.
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Morota Takashi
Pharmacognosy And Medicinal Resources Research Department Central Research Laboratories Tsumura &
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Kase Yoshio
ツムラツムラ研究所
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Miyamoto K
Department Of Hospital Pharmacy School Of Medicine Kanazawa University
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Miyamoto K
Kanazawa Univ. Hospital Ishikawa Jpn
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Takeda Shuichi
Department Of Drug Metabolism & Disposition Tsumura Research Institute Tsumura & Co.
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Aburada Masaki
Musashino Univ. Tokyo Jpn
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Miyamoto Ken'ichi
Hospital Pharmacy School Of Medicine Kanazawa University
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Takeda Shuichi
Tsumura & Co. Tsumura Research Laboratories
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Miyamoto Ken-ichi
Department of Clinical Pharmacy, Graduate School of Natural Science and Technology, Kanazawa University
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Kase Yoshihiro
Pharmacology Research Department, Central Research Laboratories, R & D Division, Tsumura & Co.
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