Effects of Rikkunshi-to, a Traditional Japanese Medicine, on the Delay of Gastric Emptying Induced by NG-Nitro-<sc>L</sc>-arginine
スポンサーリンク
概要
- 論文の詳細を見る
We evaluated the effects of Rikkunshi-to and several of its ingredients on the delay of gastric emptying induced by a nitric oxide (NO) synthase inhibitor, NG-nitro-<sc>L</sc>-arginine (<sc>L</sc>-NNA). After oral administration of <sc>L</sc>-NNA to rats, the gastric emptying rate at 24 h was decreased from 82.8 ± 2.4% to 53.3 ± 5.7%. The decrease of the gastric emptying rate induced by <sc>L</sc>-NNA treatment was markedly ameliorated by administration of Rikkunshi-to (250 and 500 mg/kg, p.o.) in a dose-dependent manner. To identify the active ingredient of Rikkunshi-to, the components were separated according to polarity, and the effects of the respective fractions on gastric emptying were evaluated. Significant efficacy was found in the water and methanol fractions, but not in the 50% aqueous-methanol fraction. Furthermore, hesperidin (1 - 4.29 mg/kg, p.o.) contained in the methanol fraction and <sc>L</sc>-arginine (4.5 mg/kg, p.o.) contained in the water fraction ameliorated the decrease in the gastric emptying rate induced by <sc>L</sc>-NNA treatment. These results suggest that Rikkunshi-to ameliorated abnormalities of NO-mediated gastric functions such as delayed gastric emptying, and hesperidin and <sc>L</sc>-arginine were identified as two of the active ingredients contributing to the ability of Rikkunshi-to to facilitate gastric emptying.
- 社団法人 日本薬理学会の論文
著者
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木戸 敏孝
株式会社ツムラ医薬評価研究所
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NOMURA Masaaki
Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan
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Nakai Yoichiro
Central Research Laboratories Tsumura & Co.
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Kido T
Department Of Medicinal Informatics Graduate School Of Medicine Kanazawa University
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Kido Toshitaka
Central Res. Laboratories Tsumura & Co.
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Kase Y
Tsumura Research Laboratories Tsumura & Co.
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Kase Yoshio
ツムラ漢方生薬研究所
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Kase Yoshio
国立長寿医療センター研究所 老年病研究部
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Kase Yoshio
Central Research Laboratories Tsumura & Co.
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Kase Yoshio
Central Research Laboratory Tsumura & Co.
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加瀬 義夫
津村薬理研究所
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TAKEDA Shuichi
Central Research Laboratories, Tsumura & Co.
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KIDO Toshitaka
Department of Medicinal Informatics, Graduate School of Medicine, Kanazawa University
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SAKAKIBARA Iwao
Central Research Laboratories, Tsumura & Co.
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ABURADA Masaki
Central Research Laboratories, Tsumura & Co.
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Nomura Masaaki
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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Nakai Yasuhiro
Fuji Central Research Laboratory Mochida Pharmaceutical Co. Ltd.
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Nakai Y
Central Research Laboratories Tsumura & Co.
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Kase Yoshio
ツムラツムラ研究所
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Takeda Shuichi
Central Research Laboratories Tsumura & Co.
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Nakamura Yuichi
Pharmacognosy & Medicinal Resources Research Department
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Nakai Yoichiro
Central Research Laboratories, Tsumura & Co.
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Sakakibara Iwao
Central Research Laboratories, Tsumura & Co.
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Kase Yoshio
Central Research Laboratories, Tsumura & Co.
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