Inhibition of P-Glycoprotein-Dependent Multidrug Resistance by an Isoquinolinesulfonamide Compound H-87 in Rat Ascites Hepatoma AH66 Cells
スポンサーリンク
概要
- 論文の詳細を見る
The effects of an isoquinolinesulfonamide compound, H-87,on naturally acquired multidrug-resistance (MDR) in rat hepatoma AH66 cells were examined. AH66 cells were highly resistant to vinblastine, SN-38,an active camptothecin analog, adriamycin, and etoposide, compared with the sensitive variant AH66F cells. Although H-87 hardly affected the sensitivities to antitumor agents of AH66F cells, this compound completely inhibited the resistance to vinblastine, moderately inhibited the resistance to SN-38 and adriamycin and had little effect on etoposide, mitomycin C, cisplatin, and 5-fluorouracil. H-87 significantly decreased the efflux of vinblastine from the resistant cells and increased the drug accumulation. SN-38 and adriamycin also exhibited a weak but significant increase in vinblastine accumulation in AH66 cells. H-87 inhibited [^3H]azidopine-photolabeling to 160 kDa P-glycoprotein in the plasma membrane of AH66 cells, as reported in acquired MDR leukemic cells. Consequently, the MDR-overcoming effect of H-87 seems to be due to its direct inhibition of the binding of antitumor agents on P-glycoprotein in the plasma membrane.
- 公益社団法人日本薬学会の論文
- 1996-06-15
著者
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NAKAMURA Seikou
Kyoto Pharmaceutical University
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中村 紳一郎
Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.
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Wakusawa Shinya
愛知学院大学 薬学部薬物治療学
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Wakusawa Shinya
Department Of Medical Technology Nagoya University School Of Health Sciences
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Wakusawa Shinya
Faculty Of Pharmaceutical Sciences Hokuriku University
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Nomura Masaaki
北陸大学 薬学部臨床薬理学
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Nomura Masaaki
北陸大学 薬学部合成化学
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Miyamoto K
Department Of Hospital Pharmacy School Of Medicine Kanazawa University:department Of Medicinal Infor
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Nomura Masaaki
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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Nomura Masaaki
Faculty Of Pharmaceutical Sciences Hokuriku University
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Nakamura S
Toyama Univ. Toyama Jpn
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MIYAMOTO Ken-ichi
Faculty of Pharmaceutical Science
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Nakamura S
Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.
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Nakamura Satoko
Osaka University Of Pharmaceutical Sciences
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NAKAMURA Shigeo
Fujiyakuhin Co., Ltd.,
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MINAMINO Tomoyoshi
Faculty of Pharmaceutical Sciences, Hokuriku University
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HIDAKA Hiroyoshi
Nagoya University School of Medicine
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Hidaka Hiroyoshi
Nagoya Univ. Sch. Of Medicine
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Narimatsu Shizuo
Laboratories Of Health Chemistry Graduate School Of Medicine Dentistry And Pharmaceutical Sciences O
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Narimatsu Shizuo
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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Nakamura S
Laboratories Of Health Chemistry Graduate School Of Medicine Dentistry And Pharmaceutical Sciences O
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Minanmino Tomoyoshi
Department Of Legal Medicine Kanazawa University School Of Medicine
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Miyamoto Ken-ichi
Faculty Of Industrial Science And Technology Science University Of Tokyo
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Wakusawa Shinya
Department Of Radiological And Medical Laboratory Sciences
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Noguchi Masamichi
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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Nomura Masaaki
Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University
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