Medicinal Flowers. XXXX.1) Structures of Dihydroisocoumarin Glycosides and Inhibitory Effects on Aldose Reducatase from the Flowers of Hydrangea macrophylla var. thunbergii
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概要
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Six dihydroisocoumarin glycosides, florahydrosides I and II, thunberginol G 8-O-β-<span style="font-variant: small-caps;">d</span>-glucopyranoside, thunberginol C 8-O-β-<span style="font-variant: small-caps;">d</span>-glucopyranoside, 4-hydroxythunberginol G 3′-O-β-<span style="font-variant: small-caps;">d</span>-glucopyranoside, and thunberginol D 3′-O-β-<span style="font-variant: small-caps;">d</span>-glucopyranoside, have been isolated from the flowers of Hydrangea macrophylla <span style="font-variant: small-caps;">Seringe</span> var. thunbergii <span style="font-variant: small-caps;">Makino</span> (Saxifragaceae) together with 20 known compounds. The chemical structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. Among the constituents, acylated quinic acid analog, neochlorogenic acid, was shown to substantially inhibit aldose reductase [IC50=5.6 µ<span style="font-variant: small-caps;">m</span>]. In addition, the inhibitory effects on aldose reductase of several caffeoylquinic acid analogs were examined for structure–activity relationship study. As the results, 4,5-O-trans-p-dicaffeoyl-<span style="font-variant: small-caps;">d</span>-quinic acid was found to exhibit a potent inhibitory effect [IC50=0.29 µ<span style="font-variant: small-caps;">m</span>].
著者
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NAKAMURA Seikou
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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MATSUDA HISASHI
Kyoto College of Pharmacy
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Zhuang Yan
Kyoto Pharmaceutical University
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Liu Jiang
Kyoto Pharmaceutical University
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Hussein Ghazi
Kyoto Pharmaceutical University
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Matsuo Kyohei
Kyoto Pharmaceutical University
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