Chemical Structures and Hepatoprotective Effects of Constituents from Cassia auriculata Leaves
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概要
- 論文の詳細を見る
An 80% aqueous acetone extract of Cassia auriculata leaves was found to show a protective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. From the 80% aqueous acetone extract, we isolated a new benzocoumarin glycoside, avaraoside I (1), and a new flavanol dimer, avaraol I (2), together with 29 known constituents. The structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. In addition, three isolated compounds, pseudosemiglabrin (15, 0.0011%), (2S)-7,4′-dihydroxyflavan(4β→8)-catechin (22, 0.00075%), and (2S)-7,4′-dihydroxyflavan(4β→8)-gallocatechin (23, 0.092%), displayed hepatoprotective effects equivalent to that of the hepatoprotective agent, silybin.
- 公益社団法人 日本薬学会の論文
著者
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NAKAMURA Seikou
Kyoto Pharmaceutical University
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ODA Yoshimi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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Ninomiya Kiyofumi
Pharmaceutical Research and Technology Institute, Kinki University
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Xu Fengming
Kyoto Pharmaceutical University
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Morikawa Toshio
Pharmaceutical Research And Technology Institute Kinki University
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Muraoka Osamu
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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Nakashima Souichi
Kyoto Pharmaceutical University
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MATSUDA HISASHI
Kyoto College of Pharmacy
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