Adhesive Interaction of Highly Malignant Hepatoma AH66F Cells with Mesothelial Cells
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概要
- 論文の詳細を見る
We investigated the mechanism of adhesion of highly malignant ascites hepatoma AH66F cells to mesothelial cells. The adhesion rate of AH66F cells to mesentery-derived mesothelial cells (M-cells) was about 46% at 37℃, but it decreased to about 27% at 4℃. The adhesion rate of AH66F cells was about 25% in the presence of leukocyte function-associated antigen 1 (LFA-1) mAb at both 4℃ and 37℃. When M-cells were treated with hyaluronidase, the AH66F/M-cell adhesion was decreased to half at 37℃ and had nearly disappeared at 4℃. The residual adhesion of AH66F cells to M-cells treated with hyaluronidase almost disappeared in the presence of LFA-1 mAb. AH66F cells strongly adhered to a hyaluronate (HA)-coated plate, but not to a bovine serum albumin-coated plate. AF66F cells expressed a CD44 molecule (a HA receptor) in the plasma membrane, with a molecular size of about 85 to 90 kDa, corresponding to the CD44H isoform.These results indicated that the adhesion of AH66F cells to mesothelial cells is composed of pathways of CD44/HA and LFA-1/ICAM-1.
- 1999-07-15
著者
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NOMURA Masaaki
Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan
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SUGIURA Yuhki
Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan
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TATSUMI Yasuaki
Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan
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MIYAMOTO Ken-ichi
Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan
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Nomura Masaaki
北陸大学 薬学部臨床薬理学
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Nomura Masaaki
北陸大学 薬学部合成化学
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Miyamoto K
Department Of Hospital Pharmacy School Of Medicine Kanazawa University:department Of Medicinal Infor
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Nomura Masaaki
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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Sugiura Yuhki
Hospital Pharmacy Kanazawa University
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Tatsumi Yasuaki
Department Of Legal Medicine Kanazawa University School Of Medicine
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Tatsumi Yasuaki
Department Of Medical Technology Nagoya University School Of Health Sciences
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Tatsumi Y
Department Of Medical Technology Nagoya University School Of Health Sciences
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Miyamoto Ken-ichi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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Noguchi Masamichi
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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Nomura Masaaki
Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University
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