Dual Regulation of Alkaline Phosphatase Activity by Calcitonin in Porcine Kidney Cells

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概要

• 論文の詳細を見る

• Intracellular signal transduction for regulation of alkaline phosphatase (ALP) activity in renal epithelial cells treated with calcitonin is not yet completely understood, although it is known that calcitonin receptors couple to cyclic AMP-dependent protein kinase (PKA) and calcium/phospholipid-dependent protein kinase (PKC). Salmon calcitonin increased the cyclic AMP content in LLC-PK_1 porcine kidney cells in a concentration-dependent manner. When the confluent cells were incubated for 47 h after a 1 h-pulse exposure or continuously exposed to calcitonin and forskolin for 48 h, ALP activity in the cells was increased by calcitonin about 2-fold compared with the basal acitivity at the maximum level but was not dependent on the exposure time; it was markedly increased by forskolin in parallel with the exposure time. The increase in activity produced by calcitonin was abolished by a PKA inhibitor H-89,and, in contrast, potentiated by a PKC inhibitor, NA-382 to near the forskolin-induced level. These results indicate that calcitonin exerts a dual-regulation of ALP activity in LLC-PK_1 cells, positively through the PKA pathway and negatively through PKC.

• 公益社団法人日本薬学会の論文
• 1997-12-15

著者

• MIYAMOTO Ken-ichi

  Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan

• YAMAMOTO Shinya

  Department of Diagnostic Radiology, Kawasaki Medical Shool

• Miyamoto Ken-ichi

  金沢大学 薬学部臨床薬物情報

• Miyamoto Ken-ichi

  Dep. Of Clinical Pharmacy Graduate School Of Natural Sci. And Technol. Kanazawa Univ.

• Miyamoto K

  Kanazawa Univ Kanazawa

• Suzuki R

  Graduate School Of Pharmaceutical Sciences Nagoya City University

• SUZUKI RYOJI

  Department of Anatomy, Akita University School of Medicine

• Suzuki Ryoji

  Department Of Anatomy Akita University School Of Medicine

• WAKI Yoshihiro

  Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan

• HORITA Takashi

  Department of Pharmacology, Faculty of Den tistry, Tokyo Medical and Dental University

• HORITA Takashi

  Faculty of Pharmaceutical Sciences, Hokuriku University

• MORITANI Shuzo

  Fukui Prefectural University College of Nursing

• Yamamoto Shinya

  Department Of Diagnostic Radiology Kawasaki Medical Shool

• Miyamoto K

  Department Of Hospital Pharmacy School Of Medicine Kanazawa University

• Horita Takashi

  Department Of Pharmacology Faculty Of Den Tistry Tokyo Medical And Dental University

• Waki Yoshihiro

  Department Of Pharmacology And Pharmaceutics Graduate School Of Natural Science And Technology Kanaz

• Waki Yoshihiro

  Department Of Pharmacology Hokuriku University School Of Pharmacy

• Suzuki R

  Division Of Pharmacy And Health Sciences Graduate School Of Natural Science And Technology Kanazawa

• Miyamoto Ken'ichi

  Hospital Pharmacy School Of Medicine Kanazawa University

• Miyamoto Ken-ichi

  Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University

• Yamamoto S

  Department Of Pharmacology And Pharmaceutics Graduate School Of Natural Science And Technology Kanaz

• Yamamoto Shinya

  Department Of Biotechnology Graduate School Of Engineering Osaka University

• Miyamoto Ken-ichi

  Department of Clinical Pharmacy, Graduate School of Natural Science and Technology, Kanazawa University

• SUZUKI Ryoji

  Department of Physics, Science University

• SUZUKI Ryoji

  Department of Physics, Science University of Tokyo

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