Synthesis and Cyclic AMP Phosphodiesterase 4 Isoenzyme Inhibitory Activity of Heterocycle Condensed Purines
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概要
- 論文の詳細を見る
To reverse the adverse reactions of alkylxanthines and to develop novel inhibitors of cyclic AMP phosphodiesterase 4 (PDE4), a series of heterocycle [a]-, [b]-, [c,d]-, and [i]-condensed purines were designed and synthesized. Although all compounds did not display PDE1 and PDE3 inhibitory activities, several heterocycle [i]-condensed purines strongly inhibited PDE4. Especially, dl-3,4-dipropyl-8-methyl-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]purin-5-one (dl-7c) exhibited comparable PDE4 inhibitory activity (IC_<50>=1.9μM) to rolipram and denbufylline(DBF).
- 社団法人日本薬学会の論文
- 2002-09-01
著者
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YAMAMOTO Kenji
Department of Medical Ecology and Informatics, Research Institute, International Medical Center of J
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MIYAMOTO Ken-ichi
Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan
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Sawanishi Hiroyuki
Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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Sawanishi H
Hokuriku Univ. Kanazawa
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Suzuki Hideyo
Toyama Prefectural Institute For Pharmaceutical Research
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Suzuki H
Toyama Prefectural Institute For Pharmaceutical Research
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Suzuki H
Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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SUZUKI Hirokazu
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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YAMAMOTO Manabu
Central Laboratory Lotte Co., Ltd.
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SHIMURA Susumu
Central Laboratory Lotte Co., Ltd.
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Yokogawa Koichi
Department Of Clinical Pharmaceutics Graduate School Of Pharmaceutical Sciences Kanazawa University
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Yokogawa Koichi
Department Of Hospital Pharmacy Kanazawa University Hospital
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Miyamoto Ken-ichi
Department Of Hospital Pharmacy School Of Medicine Kanazawa University
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Miyaamoto Ken-ichi
Department Of Medical Informatics Graduate School Of Medical Science Kanazawa University
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Miyamoto Ken-ichi
Graduate School Of Natural Science And Technology Kanazawa University
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Sawanishi Hiroyuki
Faculty Of Pharmaceutical Sciences Hokuriku University
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Suzuki H
Janssen Pharmaceutical K.k. Shizuoka Jpn
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Suzuki Hirokazu
Department Of Biomolecular Engineering Graduate School Of Engineering Tohoku University
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Yamamoto K
Faculty Of Pharmaceutical Sciences Josai University
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Shimura Susumu
Central Laboratory Lotte Co. Ltd.
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Miyamoto K
Kanazawa Univ. Hospital Ishikawa Jpn
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Sawanishi H
Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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Miyamoto Ken-ichi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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Suzuki Hirokazu
Department Of Applied Chemistry College Of Engineering Chubu University
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Yamamoto Kenji
Department Of Chemistry Hokuriku University
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Yamamoto Manabu
Central Laboratory Lotte Co. Ltd.
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Yamamoto Kenji
Department Of Cardiovascular Surgery Kanagawa Cardiovascular And Respiratory Center
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Suzuki Hirokazu
Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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