Angiostatin : An Endogenous Inhibitor of Angiogenesis and Tumor Growth
スポンサーリンク
概要
- 論文の詳細を見る
Angiogenesis is an important process of new microblood vessel formation under both physiological and pathological conditions and is likely regulated by a balance between angiogenic stimulators and inhibitors. Given the dependence of tumor growth and metastasis on angiogenesis, endogenous angiogenesis inhibitors are important for suppression of tumor progression. Angiostatin is a major endogenous angiogenesis inhibitor having the ability to regress tumor in various animal models. Although the mechanism of angiostatin formation in vivo, as well as the molecular mechanism of angiostatin action, remains elusive, in vitro studies have suggested that this protein is generated from plasminogen by multiple enzymatic actions. In this review, we describe the current understanding of the responsible proteinases for angiostatin generation and of the mechanism of angiostatin action.
- 2004-09-25
著者
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YAMAMOTO Kenji
Department of Medical Ecology and Informatics, Research Institute, International Medical Center of J
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Iwata Jun-ichi
九州大学 歯学研究院口腔機能分子科学分野
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Iwata Jun-ichi
Department Of Pharmacology Graduate School Of Dental Science Kyushu University
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KAWAKUBO Tomoyo
Department of Pharmacology, Graduate School of Dental Science, Kyushu University
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Kawakubo Tomoyo
Department Of Pharmacology Graduate School Of Dental Science Kyushu University
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Yamamoto Kenji
Department Of Cardiovascular Surgery Kanagawa Cardiovascular And Respiratory Center
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Yamamoto Kenji
Department Of Pharmacology Graduate School Of Dental Science Kyushu University
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岩田 淳一
Department of Pharmacology, Graduate School of Dental Science, Kyushu University
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