Phosphodiesterase 4 Isoenzyme Inhibitory Activity of 3-Phenylxanthines and 4-Phenyl[i]condensed-purines

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概要

• 論文の詳細を見る

• On the basis of our study on the structure-activity relationships of 1, 3, 7-alkylxanthines and condensed-purines on cAMP-phosphodiesterase 4(PDE 4)isoenzyme inhibitor, we investigated the synthesis and the inhibitory activity of 3-phenylxanthine and 4-phenyl[i]condensed-purine derivatives. Xanthines and condensed-purines with the phenyl group exhibited potent and selective PDE 4 inhibitory activity.

• 社団法人日本薬学会の論文
• 2001-02-01

著者

• YAMAMOTO Kenji

  Department of Medical Ecology and Informatics, Research Institute, International Medical Center of J

• MIYAMOTO Ken-ichi

  Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan

• Sawanishi Hiroyuki

  Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Sawanishi H

  Hokuriku Univ. Kanazawa

• YOKOGAWA Koichi

  Department of Hospital Pharmacy, School of Medicine, Kanazawa University

• Suzuki Hideyo

  Toyama Prefectural Institute For Pharmaceutical Research

• Suzuki H

  Toyama Prefectural Institute For Pharmaceutical Research

• Suzuki H

  Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• SUZUKI Hirokazu

  Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• Yokogawa Koichi

  Department Of Clinical Pharmaceutics Graduate School Of Pharmaceutical Sciences Kanazawa University

• Yokogawa Koichi

  Department Of Hospital Pharmacy School Of Medicine Kanazawa University

• Yokogawa Koichi

  Department Of Hospital Pharmacy Kanazawa University Hospital

• Miyamoto Ken-ichi

  Department Of Hospital Pharmacy School Of Medicine Kanazawa University

• Miyaamoto Ken-ichi

  Department Of Medical Informatics Graduate School Of Medical Science Kanazawa University

• Miyamoto Ken-ichi

  Graduate School Of Natural Science And Technology Kanazawa University

• Sawanishi Hiroyuki

  Faculty Of Pharmaceutical Sciences Hokuriku University

• Suzuki H

  Janssen Pharmaceutical K.k. Shizuoka Jpn

• Suzuki Hirokazu

  Department Of Biomolecular Engineering Graduate School Of Engineering Tohoku University

• Yamamoto K

  Faculty Of Pharmaceutical Sciences Josai University

• Miyamoto K

  Kanazawa Univ. Hospital Ishikawa Jpn

• Sawanishi H

  Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Yokogawa Koichi

  Department Of Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Miyamoto Ken-ichi

  Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University

• Suzuki Hirokazu

  Department Of Applied Chemistry College Of Engineering Chubu University

• Yamamoto Kenji

  Department Of Cardiovascular Surgery Kanagawa Cardiovascular And Respiratory Center

• Suzuki Hirokazu

  Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

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