FETAL TOXICITY OF AMINOGUANIDINE IN MICE AND RATS
スポンサーリンク
概要
- 論文の詳細を見る
t has been reported that aminoguanidine (AG) sulfate injected into hen's eggs at the earlier incubation stages induced retardation of development of body and liver, aplasia of gallbladder and enlarged spleen in high frequency without high mortality. The present study deals with the influence of AG against rodent animals and their fetuses. AG sulfate showed low lethality at the intraperitoneal administration against young mice and rats. When the maximum tolerated dose of AG sulfate (750 mg/kg in mice and 500 mg/kg in rats) was intraperitoneally injected into pregnant mice and rats on day 0 to 6 or day 7 to 13 of gestation, the incidence of resorption was comparatively high in the day 7 to 13 group of both species, but severe abnormalities as observed in the chick embryos and other external abnormalities were not induced in rodent fetuses. ^<14>C-AG hydrochloride intraperitoneally injected to pregnant mice on day 12 was widely distributed in the maternal body and fetuses within 1 hr and rapidly excreted. Furthermore, AG might be hardly metabolized in mice, while a metabolite clearly appeared in chick embryos. Therefore, the lower toxicity of AG on rodent animals as compared with chick embryos may be due to the fact that the agent is not metabolized and rapidly excreted from maternal body and fetuses.
- 日本トキシコロジー学会の論文
- 1986-08-25
著者
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MIYAMOTO Ken-ichi
Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan
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SUGIYAMA Takashi
Department of Obstetrics and Gynecology, Mie Unviersity School of Medicine
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Miyamoto Ken-ichi
Department Of Hospital Pharmacy School Of Medicine Kanazawa University
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Miyaamoto Ken-ichi
Department Of Medical Informatics Graduate School Of Medical Science Kanazawa University
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Miyamoto Ken-ichi
Graduate School Of Natural Science And Technology Kanazawa University
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Miyamoto K
Kanazawa Univ. Hospital Ishikawa Jpn
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Miyamoto Kenichi
Department Of Pharmacology Hokuriku University School Of Pharmacy
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KATAGIRI Shizuo
Department of Clinical Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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Miyamoto Ken-ichi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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Katagiri Shizuo
Department Of Clinical Pharmacology School Of Pharmaceutical Sciences Kitasato University
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Sugiyama Takashi
Department Of Clinical Pharmacology School Of Pharmaceutical Sciences Kitasato University
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Sugiyama Takashi
Department Of Applied Physics Saience University Of Tokyo
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