Studies on Constituents with Cytotoxic Activity from the Stem Bark of Syringa velutina
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概要
- 論文の詳細を見る
Cytotoxic compounds, oleuropein (1) and a phenylethanoid glycoside (2) were isolated from the stem bark of Syringa velutina KOM. along with coniferylaldehyde 4-O-glucoside, syringin, ligstroside, (+)-syringaresinol 4-O-glucoside, (+)-medioresinol 4"-O-glucoside and (-)-olivil 4"-O-glucoside. Phenylethanoid glycoside (2) was identified to be 3,4-dihydroxyphenylethyl alcohol 8-O-β-D-glucopyranoside. THis compound showed the most potent cytotoxic effect on several tumor cell lines (P-388,L-1210,SNU-5 and HL-60) among eitht compounds isolated in the present study. We suggest that the 3,4-dihydroxyphenylethoxy moiety of this compound contributes to cytotoxicity.
- 社団法人日本薬学会の論文
- 1999-07-15
著者
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LEE Kyung-Tae
College of Pharmacy, Kyung-Hee University
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PARK Hee-Juhn
Department of Botanical Resources, Sangji University
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MIYAMOTO Ken-ichi
Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan
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Lee Kyung-tae
韓国
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Lee Kyung-tae
College Of Pharmacy Kyung-hee University
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Lee Kyung-tae
Coll. Of Pharmacy Kyung-hee Univerisity
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Park Hee-juhn
Department Of Pharmaceutical Engineering Sangji University
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Park Hee-juhn
韓国
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Park Hee-juhn
Division Of Applied Plant Sciences Sangji University
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Park Hee-juhn
Department Of Botanical Resources Sangi University
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HAN Yong-Nam
Natural Products Research Institute, College of Pharmacy, Seoul National University
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LEE Myung-Sun
Department of Botanical Resources, Sangi University
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SOHN Il-Cheol
College of Pharmacy, Kyung-Hee University
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Lee Kyung
College Of Pharmacy Kyung Hee University
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Lee Kyung-won
韓国
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Sohn Il-cheol
College Of Pharmacy Kyung Hee University
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Sohn Il-cheol
韓国
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Han Yong-nam
Natural Products Research Institute Seoul National University
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Park Hee-joun
Department Of Botanical Resources Sangji University
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Miyamoto Ken-ichi
Department Of Hospital Pharmacy School Of Medicine Kanazawa University
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Miyaamoto Ken-ichi
Department Of Medical Informatics Graduate School Of Medical Science Kanazawa University
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Miyamoto Ken-ichi
Graduate School Of Natural Science And Technology Kanazawa University
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Miyamoto K
Kanazawa Univ. Hospital Ishikawa Jpn
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Han Yong-nam
Natural Products Research Institute College Of Pharmacy Seoul National University
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Lee Myung-sun
Department Of Botanical Resources Sangi University
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Miyamoto Ken-ichi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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