Metabolism of Kalopanaxsaponin B and H by Human Intestinal Bacteria and Antidiabetic Activity of Their Metabolites
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概要
- 論文の詳細を見る
To investigate the relationship between the intestinal bacterial metabolism of kalopanaxsaponin B and H from Kalopanix pictus (Araliaceae), and their antidiabetic effect, kalopanaxsaponin B and H were metabolized by human interstinal microfiora and the antidiabetic activity of their metabolites was measured. Human intestinal microflora metabolized kalopanaxsaponin B to kalopanaxaponin A, hederagenin 3-O-α-L-arabinopyranoside and hedaragenin. The main metabolites of kalopanaxsaponin B were kalopanaxsaponin A and hederagenin. Kalopanaxsaponin H was metabolized to kalopanaxsaponin A and I, hederagenin 3-O-α-L-arabinopyranoside and hederagenin. The main metabolites of kalopanaxsaponin H were kalopanaxsaponin I and hederagenin. Among kalopanaxsaponin B, H and their metabolites, kalopanaxsaponin A showed the most potent antidiabetic activity, followed by hederagenin. However, the main components, kalopanaxsaponin B and H, in K. pictus were inactive.
- 社団法人日本薬学会の論文
- 1998-04-15
著者
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PARK Hee-Juhn
Department of Botanical Resources, Sangji University
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Kim Dong-hyun
College Of Pharmacy Kyung Hee University
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BAE Eun-Ah
Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung H
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BAE Eun-Ah
College of Pharmacy, Kyung Hee University
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YU Ki-Woong
College of Pharmacy
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Bae Eun-ah
韓国
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Bae Eun-ah
Department Of Food And Nutrition Kyung Hee University
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Choi Jongwon
Coll. Of Pharmacy Kyungsung Univ.
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Choi Jong-won
韓国
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Choi Jong-won
College Of Pharmacy Kyung-sung University
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Yu Ki-woong
韓国
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Park Hee-juhn
Department Of Pharmaceutical Engineering Sangji University
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Park Hee-juhn
韓国
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Park Hee-juhn
Division Of Applied Plant Sciences Sangji University
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Park Hee-juhn
Department Of Botanical Resources Sangi University
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Kim Deog
College Of Pharmacy Kyung Hee University
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Kim D‐h
College Of Pharmacy Kyung Hee University
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Bae E‐a
College Of Pharmacy Kyung Hee University
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Choi Jong-won
Coll. Of Pharmacy Kyungsung Univ.
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Choi Jung-hye
Department Of Internal Medicine Hanyang University
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Park Hee-joun
Department Of Botanical Resources Sangji University
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Bae Eun-ah
Department Of Life And Nanopharmaceutical Sciences And Department Of Pharmaceutical Science Kyung He
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Kim Dong-hyun
Department Of Life And Nanopharmaceutical Sciences And Department Of Pharmaceutical Science Kyung He
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Kim D‐h
Taegu Univ. Kyungbuk Kor
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Choi Jung-hye
Dep. Of Oriental Pharmaceutical Sci. Coll. Of Pharmacy Kyung Hee Univ.
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Choi Jeongeun
College Of Pharmacy Kyungsung University
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Kim Dong-hyun
College Of Pharmacy
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