Hepatoprotective Effects of Irisolidone on tert-Butyl Hyperoxide-Induced Liver Injury(Pharmacognosy)
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概要
- 論文の詳細を見る
To clarify the hepatoprotective effects of kakkalide and its metabolite irisolidone by human fecal microflora, their effects on tert-butyl hydroperoxide (t-BHP)-injured HepG2 cells and mice were investigated. Irisolidone protected HepG2 cells against cytotoxicity induced by t-BHP. However, kakkalide did not protect cytotoxicity. When kakkalide 100 mg/kg was orally administered to mice injured by t-BHP, it significantly inhibited the increase in plasma alanine aminotransferase and aspartate aminotransferase activities by 84% and 85% of t-BHP-treated control group, respectively. The inhibitory effect of kakkalide is much more potent than that of silybin, a hepatoprotective agent. However, intraperitoneally administered kakkalide did not exhibit hepatoprotective activity. When irisolidone was intraperitoneally administered to mice, it exhibited potent hepatoprotective activity. Based on these findings, irisolidone can be hepatoprotective and kakkalide may be a prodrug transformed to irisolidone.
- 社団法人日本薬学会の論文
- 2005-03-01
著者
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BAE Eun-Ah
College of Pharmacy, Kyung Hee University
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KIM Dong-Hyun
Kyung-Hee University
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Bae Eun-ah
韓国
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Kim D‐h
College Of Pharmacy Kyung Hee University
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Bae E‐a
College Of Pharmacy Kyung Hee University
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Lee H‐u
College Of Pharmacy Kyung Hee University
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LEE Hae
Kyung Hee University, College of Pharmacy
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BAE Eun
Kyung Hee University, College of Pharmacy
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KIM Dong
Kyung Hee University, College of Pharmacy
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Bae Eun-ah
Department Of Life And Nanopharmaceutical Sciences And Department Of Pharmaceutical Science Kyung He
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Kim D‐h
Taegu Univ. Kyungbuk Kor
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Lee Hae-Ung
Kyung Hee University, College of Pharmacy
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Bae Eun-Ah
Kyung Hee University, College of Pharmacy
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