Ginsenoside Rh2 Reduces Ischemic Brain Injury in Rats (Pharmacognosy)
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概要
- 論文の詳細を見る
Ginseng was incubated under mildly acidic conditions and its inhibitory effect on a rat ischemia-reperfusion model was investigated. When ginseng was treated with 0.1% hydrochloric acid at 60 ℃, its protopanaxadiol saponins were transformed to diasteromeric ginsenoside Rg3 and Δ^<20>-ginsenoside Rg3. When the transformed ginseng extract, of which the main component was ginsenosides Rg3, was treated with human intestinal microflora, the main metabolite was ginsenoside Rh2. Orally administered acid-treated ginseng (AG) extract and ginsenoside Rh2 potently protect ischemia-reperfusion brain injury. The ginsenoside Rh2 also inhibited prostaglandin-E_2 synthesis in lipopolysaccharide-stimulated RAW264.7 cells, but showed no in vitro antioxidant activity. These results suggest that AG and ginsenoside Rh2 can improve ischemic brain injury.
- 社団法人日本薬学会の論文
- 2004-03-01
著者
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Kim Dong-hyun
College Of Pharmacy Kyung Hee University
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PARK Eun-Kyung
College of Pharmacy, Kyung Hee University
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CHOO Min-Kyung
College of Pharmacy, Kyung Hee University
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OH Jin
College of Pharmacy, Kyung Hee University
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RYU Jong
College of Pharmacy, Kyung Hee University
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Park Eun-kyung
韓国
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Park Eun-kyung
College Of Pharmacy Kyung Hee University
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Park Eun
Department Of Biochemistry Kon Kuk University
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Kim Deog
College Of Pharmacy Kyung Hee University
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Choo Min-kyung
College Of Pharmacy Kyung Hee University
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Choo Min-kyung
韓国
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Kim D‐h
College Of Pharmacy Kyung Hee University
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Ryu Jong
College Of Pharmacy Kyung Hee University
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Park E‐k
College Of Pharmacy Kyung Hee University
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Kim Dong-hyun
Department Of Life And Nanopharmaceutical Sciences And Department Of Pharmaceutical Science Kyung He
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Kim D‐h
Taegu Univ. Kyungbuk Kor
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Kim Dong-hyun
College Of Pharmacy
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