3-Methylethergalangin Isolated from Alpinia officinarum Inhibits Pancreatic Lipase
スポンサーリンク
概要
- 論文の詳細を見る
The pancreatic lipase inhibitory activity of the rhizome of Alpinia officinarum (AO) and its antihyperlipidemic activity were measured. When the water extract of AO was fractionated stepwise with organic solvents, the ethyl acetate fraction exhibited the most potent inhibition. 3-Methylethergalangin was isolated from that fraction as an inhibitor of pancreatic lipase with an IC_<50> value of 1.3mg/ml (triolein as a substrate). AO and its ethyl acetate fraction significantly inhibited the serum TG level in corn oil feeding-induced triglyceridemic mice, and serum triglyceride (TG) and cholesterol in Triton WR-1339-induced hyperlipidemic mice. However, this compound and the AO ethyl acetate fraction did not show hypolipidemic activity in high cholesterol diet-induced hyperlipidemic mice. The results suggest that the hypolipidemic activity of AO and 3-methylethergalangin is due to the inhibition of pancreatic lipase.
- 公益社団法人日本薬学会の論文
- 2003-06-01
著者
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Kim Dong-hyun
College Of Pharmacy Kyung Hee University
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HAN Myung
Department of Food and Nutrition, Kyung Hee University
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CHOO Min-Kyung
College of Pharmacy, Kyung Hee University
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Han Myung
韓国
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Han Myung
Department Of Food And Nutrition Kyung Hee University
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Han Myung
Department Of Food Science Kyung Hee University
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Kim Dong-hyun
Td Team R&d Center Samsung Electronics Co.ltd.
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Shin Ji-eun
韓国
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Kim Doo-young
School Of Electrical Eng. Seoul National Univ.
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Shin J‐e
Kyung Hee Univ. Seoul Kor
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Shin Ji-eun
Department Of Food Science Kyung Hee University:college Of Pharmacy Kyung Hee University
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Kim Dong-hee
Korea Research Institute Of Bioscience And Biotechnology
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Kim Do-hoon
Department Of Psychiatry College Of Medicine Institute Of Natural Medicine Hallym University
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Han M
Department Of Food And Nutrition Kyung Hee University
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Kim D‐h
College Of Pharmacy Kyung-hee University
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Kim D‐h
Department Of Psychiatry College Of Medicine Institute Of Natural Medicine Hallym University
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Kim Dong-hyun
College Of Pharmacy
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