Serotonin Depletion Enhances the Intracerebroventricularly Administered MK-801-Induced Plasma Interleukin-6 Levels in Mice
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概要
- 論文の詳細を見る
To investigate the effect of serotonin depletion on the intracerebroventricularly (I.c.v.) administered MK-801-induced plasma interleukin-6 (IL-6) levels, we pretreated mice with parachlorophenylalanine (PCPA, 300mg/kg, I.p.) 3d before an I.c.v. injection of MK-801 (1μg). The I.c.v. MK-801-induced rise of plasma IL-6 level was markedly enhanced in the PCPA-pretreated mice. However, serotonin depletion by PCPA pretreatment did not affect the I.c.v. MK-801-induced increase in plasma corticosterone level. These results suggest that serotonergic system is involved in the suppressive regulation of MK-801-induced plasma IL-6 level.
- 社団法人日本薬学会の論文
- 2003-04-01
著者
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Kim Dong-hyun
Td Team R&d Center Samsung Electronics Co.ltd.
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Suh Hong-won
韓国
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Suh Hong-won
Department Of Pharmacology College Of Medicine Institute Of Natural Medicine Hallym University
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Kim Doo-young
School Of Electrical Eng. Seoul National Univ.
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Moon Yoo-sun
Department Of Family Medicine College Of Medicine Hallym University
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Moon Yoo-sun
韓国
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Song D‐k
Department Of Pharmacology Hallym University College Of Medicine Institute Of Natural Medicine
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Suh H‐w
Department Of Pharmacology College Of Medicine Institute Of Natural Medicine Hallym University
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JUNG Jun-Sub
Department of Pharmacology, Hallym University College of Medicine, Institute of Natural Medicine
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SONG Dong-Keun
Department of Pharmacology, Hallym University College of Medicine, Institute of Natural Medicine
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Song Dong-keun
Department Of Pharmacology And Institute Of Natural Medicine College Of Medicine Hallym University
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Song Dong-keun
Department Of Pharmacology College Of Medicine Institute Of Natural Medicine Hallym University
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Jung J‐s
Department Of Pharmacology Hallym University College Of Medicine Institute Of Natural Medicine
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Jung Jun-sub
Dep. Of Pharmacology Hallym Univ. Coll. Of Medicine Inst. Of Natural Medicine
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Jung Jun-sub
Department Of Pharmacology College Of Medicine Institute Of Natural Medicine Hallym University
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KIM Do-Hoon
Department of Psychiatry, College of Medicine, Hallym University
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Kim Dong-hee
Korea Research Institute Of Bioscience And Biotechnology
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Kim Do-hoon
Department Of Psychiatry College Of Medicine Institute Of Natural Medicine Hallym University
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Kim D‐h
College Of Pharmacy Kyung-hee University
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Kim D‐h
Department Of Psychiatry College Of Medicine Institute Of Natural Medicine Hallym University
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Suh Hong-won
Department Of Pharmacology College Of Medicine And Institute Of Natural Medicine Hallym University
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Kim Do-hoon
Department Of Electrical And Electronic Engineering Yonsei University
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