Antinociceptive Profiles of Crude Extract from Roots of Angelica gigas NAKAI in Various Pain Models(Pharmacognosy)

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概要

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• To characterize the antinociceptive profiles of Angelica gigas NAKAI (ANG; Korean angelica), methanol extract from the dried roots of ANG was made and mice were administered orally at the various doses (from 0.25 to 3 g/kg). ANG produced the increased latencies of the tail-flick and hot-plate paw-licking responses in a dosedependent manner. In acetic acid-induced writhing test, ANG dose-dependently decreased writhing numbers. Moreover, the cumulative response time of nociceptive behaviors induced by intraplantar formalin injection was reduced during both the 1st and the 2nd phases in a dose-dependent manner in ANG-treated mice. Furthermore, oral administration of ANG did not cause licking, scratching and biting responses induced by TNF-α (100 pg), IFN-γ (100 pg) or IL-1β (100 pg) injected intrathecally (i.t.), especially at higher dose (3 g/kg). Additionally, in ANG treated mice, the cumulative nociceptive response time for i.t. administration of substance P or capsaicin was dose-dependently diminished. Finally, nociceptive responses elicited by i.t. injection of glutamate (20μg), N-methyl-D-aspartic acid (60 ng), α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (13 ng) or kainic acid (12 ng) were decreased by oral administration of ANG. Our results suggest that ANG produces antinociception via acting on the central nervous system and shows antinociceptive profiles in various pain models, especially inflammatory pain.

• 公益社団法人日本薬学会の論文
• 2003-09-01

著者

• Suh Hong-won

  Department Of Pharmacology College Of Medicine Institute Of Natural Medicine Hallym University

• LEE Han-Kyu

  Department of Pharmacology, College of Medicine, Institute of Natural Medicine, Hallym University

• Lee Han-kyu

  Department Of Pharmacology College Of Medicine And Institute Of Natural Medicine Hallym University

• Han Eun-jung

  Department Of Pharmacology College Of Medicine And Institute Of Natural Medicine Hallym University

• Han Ki-jung

  Department Of Pharmacology College Of Medicine And Institute Of Natural Medicine Hallym University

• CHOI Seong-Soo

  Department of Pharmacology, College of Medicine, and Institute of Natural Medicine, Hallym Universit

• Choi Seong-soo

  Department Of Pharmacology College Of Medicine And Institute Of Natural Medicine Hallym University

• Suh Hong-won

  Department Of Pharmacology College Of Medicine And Institute Of Natural Medicine Hallym University

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