Antinociceptive Profiles and Mechanisms of Orally Administered Coumarin in Mice
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概要
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In the present study, the antinociceptive profiles of coumarin were examined in ICR mice. Coumarin administered orally (from 1 to 10 mg/kg) showed an antinociceptive effect in a dose-dependent manner as measured in the acetic acid-induced writhing test. Duration of antinociceptive action of coumarin maintained at least for 60 min. But, the cumulative response time of nociceptive behaviors induced by a subcutaneous (s.c.) formalin injection, intrathecal (i.t.) substance P (0.7 µg) or glutamate (20 µg) injection was not affected by coumarin. In addition, intracerebroventricular (i.c.v.) or intrathecal (i.t.) administration with coumarin (10–40 µg) attenuated acetic acid-induced writhing response in a dose dependent manner. Intraperitoneal (i.p.) pretreatment with naloxone (an opioid receptor antagonist) attenuated antinociceptive effect induced by coumarin in the writhing test. Furthermore, i.c.v. or i.t. pretreatment with naloxone (5 µg) reversed the decreased acetic acid-induced writhing response. However, methysergide (a 5-HT serotonergic receptor antagonist) or yohimbine (an α2-adrenergic receptor antagonist) did not affect antinociception induced by coumarin in the writhing test. Our results suggest that coumarin exerts a selective antinociceptive property in the acetic acid-induced visceral-derived pain model. Furthermore, the antinociceptive effect of coumarin may be mediated by activation of central opioid receptors, but not serotonergic and adrenergic receptors.
著者
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Kim Sung-su
Department Of Pharmaceutical Biochemistry And Kyung Hee East-west Pharmaceutical Research Institute
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Kim Su-jin
Department Of Atmospheric Sciences Yonsei University
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Suh Hong-won
Department Of Pharmacology College Of Medicine And Institute Of Natural Medicine Hallym University
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Kang Yu-Jung
Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University
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Park Soo-Hyun
Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University
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Kim Chea-Ha
Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University
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Sim Yun-Beom
Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University
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Lim Su-Min
Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University
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Kim Su-Jin
Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University
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Kim Sung-Su
Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University
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