Protective Effect of Lignans against Sepsis from the Roots of Saururus chinensis(Pharmacognosy)

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概要

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• In the course of isolating preventive agents from sepsis based on the in vivo assay model from the EtOAc extract of the roots of Saumrus chinensis, twelve lignans, sarisan (1), eryrthro-austrobailignan-6 (2), meso-dihydroguaiaretic acid (3), saucerneol B (4), manassantin B (5), manassantin A (6), rel-(8R,8'R)-dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydro-furan (7), (+)-saururinone (8), sauchinone (9), sauchinone B (10), nectandrin B (11) and machilin D (12), were isolated. Compounds 9 and 10, at a dose of 10 mg/kg, increased survival rates to 80% from 20% for the control experiment, and decreased the plasma levels of tumor necrosis factor-α (TNF-α) and alanine aminotransferase (ALT) activity in mice administered LPS/D-GalN.

• 社団法人日本薬学会の論文
• 2008-03-01

著者

• JAHNG Yurngdong

  College of Pharmacy, Yeungnam University

• Song D‐k

  Department Of Pharmacology Hallym University College Of Medicine Institute Of Natural Medicine

• Son Jong-keun

  College Of Pharmacy Yeungnam University

• Chang Hyuen

  College Of Pharmacy Yeungnam University

• Chang Hyuen

  韓国

• Jahng Yurngdong

  Coll. Of Pharmacy Yeungnam Univ.

• Jahng Yurngdong

  College Of Pharmacy Yeungnam University

• SEO Chang-Seob

  College of Pharmacy, Yeungnam University

• LEE Yeun-Kyung

  College of Pharmacy, Yeungnam University

• KIM Young-Jin

  College of Pharmacy, Yeungnam University

• JUNG Jun-Sub

  Department of Pharmacology, Hallym University College of Medicine, Institute of Natural Medicine

• CHANG Hyun-Wook

  College of Pharmacy, Yeungnam University

• SONG Dong-Keun

  Department of Pharmacology, Hallym University College of Medicine, Institute of Natural Medicine

• Chang Hyun-wook

  Coll. Of Pharmacy Yeungnam Univ.

• Chang Hyun-wook

  College Of Pharmacy Yeungnam University

• Seo Chang-seob

  Coll. Of Pharmacy Yeungnam Univ.

• Seo Chang-seob

  College Of Pharmacy Yeungnam University

• Song Dong-keun

  Department Of Pharmacology And Institute Of Natural Medicine College Of Medicine Hallym University

• Song Dong-keun

  Department Of Pharmacology College Of Medicine Institute Of Natural Medicine Hallym University

• Jung J‐s

  Department Of Pharmacology Hallym University College Of Medicine Institute Of Natural Medicine

• Jung Jun-sub

  Dep. Of Pharmacology Hallym Univ. Coll. Of Medicine Inst. Of Natural Medicine

• Jung Jun-sub

  Department Of Pharmacology College Of Medicine Institute Of Natural Medicine Hallym University

• Kim Hyo-jin

  韓国

• Lee Yeun-kyung

  College Of Pharmacy Yeungnam University

• Kim Young-jin

  College Of Pharmacy Yeungnam University

• Lee Yuen-Kyung

  College of Pharmacy, Yeungnam University

関連論文

• Inhibition of Nitric Oxide and Tumor Necrosis Factor-α (TNF-α) Production by Propenone Compound through Blockade of Nuclear Factor (NF)-κB Activation in Cultured Murine Macrophages (Biochemistry/Molecular Biology)
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• Agents Protecting against Sepsis from the Roots of Angelica dahurica(Pharmacognosy)
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