Synthesis and Biological Properties of Benzo-Annulated Rutaecarpines
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概要
- 論文の詳細を見る
A series of benzo-annulated rutaecarpines were prepared from anthranilic acid and 3-aminonaphthalene-2-carboxylic acid by Fischer indole synthesis as key reaction. Cytotoxicity was somewhat increased by the introduction of benzo-annulation, which was not directly related to the inhibitory activity against topoisomerases (topo) I and II. Benzo-annulation on ring A led to significant increase of inhibitory activity against topo II while annulations on ring E increased inhibitory activity against topo I.
- 公益社団法人 日本薬学会の論文
著者
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Son Jong
College Of Pharmacy Yeungnam University
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Jahng Yurngdong
College Of Pharmacy Yeungnam University
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Kwon Youngjoo
College of Pharmacy, Ewha Womans University
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Lee Seung
College Of Pharmacy And Cbitrc Chungbuk National University
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Hong Young
College of Pharmacy, Yeungnam University
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Lee Woo
College of Pharmacy, Yeungnam University
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Kim Hye-Lin
College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University
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Nam Jung
College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University
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Kwon Youngjoo
College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University
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Nam Jung
College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University
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Kim Hye-Lin
College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University
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