Pinusolide Isolated from Biota orientalis Inhibits 5-Lipoxygenase Dependent Leukotriene C4 Generation by Blocking c-Jun N-Terminal Kinase Pathway in Mast Cells
スポンサーリンク
概要
- 論文の詳細を見る
Pinusolide, an herbal medicine isolated from Biota orientalis L. (B. orientalis), inhibited 5-lipoxygenase (5-LO)-dependent leukotriene C4 (LTC4) generation in immunoglobulin E (IgE)/Ag-induced bone marrow-derived mast cells (BMMCs) in a concentration-dependent manner. To clarify the action mechanism of pinusolide on the inhibition of LTC4 generation, we examined the effect of pinusolide on phosphorylation of cytosolic phospholipase A2 (cPLA2), as well as translocation phospho-cPLA2 and 5-LO to nucleus. Inhibition of LTC4 generation by pinusolide was accompanied by a decrease in cPLA2 phosphorylation which occurred via a decrease in intracellular Ca2+ influx and blocking the c-Jun N-terminal kinase (JNK) pathways. However, pinusolide had no effect on extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein (MAP) kinas phosphorylation. Taken together, the present results suggest that potent inhibition of 5-LO dependent LTC4 generation by pinusolide requires both suppression of calcium influx and JNK phosphorylation.
- 公益社団法人 日本薬学会の論文
著者
-
SON Jong
College of Pharmacy, Yeungnam University
-
Son Jong
College Of Pharmacy Yeungnam University
-
Chang Hyeun
College Of Pharmacy Yeungnam University
-
Yang Hyun
Natural Products Res. Center Korea Inst. Of Sci. And Technol.
-
Jin Ye
College of Pharmacy, Yeungnam University
-
Yang Hyun
Natural Medicine Center Korea Inst. Of Sci. And Technol.
-
Yang Hyun
Natural Medicine Center, Korea Institute of Science and Technology
関連論文
- Autophagy Inhibition Enhances Apoptosis Induced by Ginsenoside Rk1 in Hepatocellular Carcinoma Cells
- Effect of Dexamethasone on STAT6-Dependent Ym1/2 Expression in Vivo and in Vitro(Biochemistry)
- Anti-inflammatory Activity of Pectolinarigenin and Pectolinarin Isolated from Cirsium chanroenicum(Pharmacology)
- Ochnaflavone, Naturally Occurring Biflavonoid, Inhibits Phospholipase A_2 Dependent Phosphatidylethanolamine Degradation in a CCl_4-Induced Rat Liver Microsome(Biochemistry)
- Effects of Anti-inflammatory Biflavonoid, Ginkgetin, on Chronic Skin Inflammation(Pharmacology)
- Anti-inflammatory Activity of Ailanthus altissima in Ovalbumin-Induced Lung Inflammation(Biochemistry)
- Anti-asthmatic Activity of an Ethanol Extract from Saururus chinensis(Biochemistry)
- Ginkgetin, a Biflavone from Ginko biloba Leaves, Inhibits Cyclooxygenases-2 and 5-Lipoxygenase in Mouse Bone Marrow-Derived Mast Cells(Biochemistry)
- Saponins and Other Constituents from the Leaves of Aralia elata
- Antiinflammatory Activity of Astilbic Acid from Astilbe chinensis(Biochemistry/Molecular Biology)
- Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms
- Triterpenoid Saponins from the Roots of Sophora koreensis
- Phenolic Glycosides from Pyrola japonica
- Inhibitory Effects of Nardostachin on Nitric Oxide, Prostaglandin E_2, and Tumor Necrosis Factor-α Production in Lipopolysaccharid Activated Macrophages(Biochemistry/Molecular Biology)
- Tyrosinase Inhibitory Prenylated Flavonoids from Sophora flavescens(Pharmacology)
- Dual Inhibition of Cyclooxygenases-2 and 5-Lipoxygenase by Deoxypodophyllotoxin in Mouse Bone Marrow-Derived Mast Cells(Biochemistry/Molecular Biology)
- Inhibition of Nitric Oxide and Tumor Necrosis Factor-α (TNF-α) Production by Propenone Compound through Blockade of Nuclear Factor (NF)-κB Activation in Cultured Murine Macrophages (Biochemistry/Molecular Biology)
- Antiasthmatic Activity of Luteolin-7-O-glucoside from Ailanthus altissima through the Downregulation of T Helper 2 Cytokine Expression and Inhibition of Prostaglandin E2 Production in an Ovalbumin-Induced Asthma Model
- The Naturally Occurring Flavolignan, Deoxypodophyllotoxin, Inhibits Lipopolysaccharide-Induced iNOS Expression through the NF-kB Activation in RAW264.7 Macrophage Cells(Highlighted paper selected by Editor-in-chief,Biochemistry)
- Papyriflavonol A from Broussonetia papyrifera Inhibits the Passive Cutaneous Anaphylaxis Reaction and Has a Secretory Phospholipase A_2-Inhibitory Activity
- Expression of Cyclooxygenase-2 and Pro-inflammatory Cytokines Induced by 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) in Human Mast Cells Requires NF-κB Activation
- Asterosaponins Isolated from the Starfish Asterias amurensis
- Anticancer Constituents from the Roots of Rubia cordifolia L.
- Iridoid Esters from Patrinia saniculaefolia
- Detection and Characterization of a Type IIA Secretory Phospholipase A_2 Inhibitory Protein in Human Amniotic Fluid
- cDNA Cloning and Expression of Biologically Active Platelet Activating Factor-Acetylhydrolase (PAF-AH) from Bovine Mammary Gland(Biochemistry/Molecular Biology)
- Saucerneol G, a New Lignan, from Saururus chinensis Inhibits Matrix Metalloproteinase-9 Induction via a Nuclear Factor κB and Mitogen Activated Protein Kinases in Lipopolysaccharide-Stimulated RAW264.7 Cells
- A New Acylated Triterpene from the Roots of Chaenomeles japonica
- Anti-tumor Activity of the Ginsenoside Rk1 in Human Hepatocellular Carcinoma Cells through Inhibition of Telomerase Activity and Induction of Apoptosis(Molecular and Cell Biology)
- Inhibition of Prostaglandin Production by a Structurally-Optimized Flavonoid Derivative, 2',4',7-Trimethoxyflavone and Cellular Action Mechanism(Biochemistry)
- Loniceroside C, an Antiinflammatory Saponin from Lonicera japonica
- Cyclooxygenase-2 Inhibitory Cerebrosides from Phytolaccae Radix
- Purification and Characterization of 45 kDa PAF Acetylhydrolase from Bovine Colostrum(Biochemistry)
- Batatasin I, a Naturally Occurring Phenanthrene Derivative, Isolated from Tuberous Roots of Dioscorea batatas Suppresses Eicosanoids Generation and Degranulation in Bone Marrow Derived-Mast Cells
- Alleviation of OVA-Induced Airway Inflammation by Flowers of Inula japonica in a Murine Model of Asthma
- Autophagy Inhibition Enhances Apoptosis Induced by Ginsenoside Rk1 in Hepatocellular Carcinoma Cells
- Luteolin-7-O-glucoside Suppresses Leukotriene C4 Production and Degranulation by Inhibiting the Phosphorylation of Mitogen Activated Protein Kinases and Phospholipase Cγ1 in Activated Mouse Bone Marrow-Derived Mast Cells
- Synthesis and Biological Properties of Benzo-Annulated Rutaecarpines
- Alleviation of OVA-Induced Airway Inflammation by Flowers of Inula japonica in a Murine Model of Asthma
- Manassantin A Isolated from Saururus chinensis Inhibits 5-Lipoxygenase-Dependent Leukotriene C4 Generation by Blocking Mitogen-Activated Protein Kinase Activation in Mast Cells
- Aldgamycin I, an antibacterial 16-membered macrolide from the abandoned mine bacterium, Streptomyces sp. KMA-001
- 6-Hydroxymethyl-1-phenazine-carboxamide and 1,6-phenazinedimethanol from a marine bacterium, Brevibacterium sp. KMD 003, associated with marine purple vase sponge
- Natural Vanadium-Containing Jeju Groundwater Inhibits Immunoglobulin E-Mediated Anaphylactic Reaction and Suppresses Eicosanoid Generation and Degranulation in Bone Marrow Derived-Mast Cells
- Pinusolide Isolated from Biota orientalis Inhibits 5-Lipoxygenase Dependent Leukotriene C4 Generation by Blocking c-Jun N-Terminal Kinase Pathway in Mast Cells
- Citreorosein Inhibits Production of Proinflammatory Cytokines by Blocking Mitogen Activated Protein Kinases, Nuclear Factor-κB and Activator Protein-1 Activation in Mouse Bone Marrow-Derived Mast Cells
- Deoxypodophyllotoxin Inhibits the Expression of Intercellular Adhesion Molecule-1 Induced by Tumor Necrosis Factor-.ALPHA. in Murine Lung Epithelial Cells
- Pheophytin a and Chlorophyll a Identified from Environmentally Friendly Cultivation of Green Pepper Enhance Interleukin-2 and Interferon-γ in Peyer's Patches ex Vivo