Cyclooxygenase-2 Inhibitory Cerebrosides from Phytolaccae Radix

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概要

• 論文の詳細を見る

• A mixture of cerebrosides, called poke-weed cerebrosides, was purified from Phytolaccae Radix(Phytolaccaceae)and characterized as 1-O-β-_D-glucopyranosides of phytosphingosine type ceramides comprised of a common long chain base(2S, 3S, 4R, 8Z)-2-amino-8-octadecene-1, 3, 4-triol and fatty acids. The fatty acyl chain of ceramide moieties was determined as(2R)-2-hydroxypentacosanoic acid, (2R)-2-hydroxylignoceric acid, (2R)-2-hydroxylignoceric acid, (2R)-2-hydroxylignoceric acid, (2R)-2-hydroxylignoceric acid, and plamitic acid. The pokeweed cerebroside inhibited the cyclooxygenase-2-dependent phase of prostaglandin D_2 generation in bone marrow-derived mast cells in a concentration dependent manner with an IC_<50> of 6.2μg/ml.

• 公益社団法人日本薬学会の論文
• 2001-03-01

著者

• CHANG Hyeun

  College of Pharmacy, Yeungnam University

• Kim Ju

  Natural Products Research Institute And College Of Pharmacy Seoul National University

• Kim Hyun

  College Of Pharmacy Kangwon National University

• SON Kun

  Department of Food Nutrition, Andong National University

• KANG Sam

  Natural Products Institute, Seoul National University

• Kim Jin

  韓国

• Son K

  Department Food & Nutriton Andong National University

• Son Jong

  Coll. Of Pharmacy Yeungnam Univ.

• Chang Hyeun

  College Of Pharmacy Yeungnam University

• Kang Sam

  韓国

• Kang Sam

  Natural Product Research Institute Seoul National University

• Chang Hyeun

  Coll. Of Pharmacy Yeungnam Univ.

• Son Kun

  Department Food & Nutriton Andong National University

• Kang S

  Natural Products Research Institute And College Of Pharmacy Seoul National University

• Kim Ju

  Natural Products Res. Inst. And Coll. Of Pharmacy Seoul National Univ.

• Chang H

  College Of Pharmacy Yeungnam University

• Kim Hyun

  College Of Pharmacy And Research Institute Of Drug Development Chonnam National University

• Kim Hyun

  College Of Electrical & Computer Engineering Chungbuk National University

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