Antioxidant Activity of Jionoside D from Clerodendron trichotomum(Biochemistry/Molecular Biology)
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概要
- 論文の詳細を見る
The antioxidant property of jionoside D, isolated from Clerodendron trichotomum (Verbenaceae), was investigated. This compound showed scavenging activity of intracellular reactive oxygen species and of 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical, as well as lipid peroxidation inhibitory activity. This radical scavenging activity of jionoside D protected the cell viability of Chinese hamster lung fibroblast (V79-4) cells exposed H_2O_2. Furthermore, jionoside D reduced the apoptotic cells induced by H_2O_2, as demonstrated by the decreased number of sub G_1 hypo-diploid cells and apoptotic body formation. However, it increased the activities of cellular antioxidant enzymes, superoxide dismutase and catalase. Taken together, these findings suggest that jionoside D, isolated from C. trichotomum, exhibits antioxidant properties.
- 社団法人日本薬学会の論文
- 2004-10-01
著者
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Kim Ju
Natural Products Research Institute And College Of Pharmacy Seoul National University
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KANG Sam
Natural Products Institute, Seoul National University
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Kim Jin
韓国
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Lee Youngki
Department of Electronics and Computer Engineering, Hanyang University
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Son Jong
Coll. Of Pharmacy Yeungnam Univ.
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Kang Sam
韓国
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Kang Sam
Natural Products Research Institute And College Of Pharmacy Seoul National University
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Lee Y
Laboratory Of Radiation Effect Korea Cancer Center Hospital
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Kang Sam
Natural Product Research Institute Seoul National University
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Lee Youngki
Department Of Electronics And Computer Engineering Hanyang University
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Kang Kyoung
School Of Medicine And Applied Radiological Science Research Institute Cheju National University
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KANG Kyoung
Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute,
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HYUN Jin
Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute,
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CHAE Sungwook
Natural Products Research Institute and College of Pharmacy, Seoul National University
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BU Hyung
Department of Biochemistry and Applied Radiological Science Research Institute, College of Medicine,
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Hyun Jin
School Of Medicine And Applied Radiological Science Research Institute Cheju National University
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Lee Youngki
Laboratory Of Radiation Effect Korea Cancer Center Hospital
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Kang S
Natural Products Research Institute And College Of Pharmacy Seoul National University
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Chae Sungwook
Department Of Biochemistry College Of Medicine And Applied Radiological Science Research Institute C
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Bu Hyung
Department Of Biochemistry And Applied Radiological Science Research Institute College Of Medicine C
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Kim Ju
Natural Products Res. Inst. And Coll. Of Pharmacy Seoul National Univ.
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Chae S
Department Of Biochemistry College Of Medicine And Applied Radiological Science Research Institute C
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Chae Sungwook
Natural Products Research Institute And College Of Pharmacy Seoul National University
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Hyun Jin
Department Of Biochemistry College Of Medicine Cheju National University
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KANG Kyoung
College of Medicine, Jeju National University
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