Cytotoxic Effect of 7β-Hydroxycholesterol on Human NCI-H460 Lung Cancer Cells(Molecular and Cell Biology)

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概要

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• The cytotoxic activity of 7β-hydroxycholesterol (7β-OHC) was evaluated on human NCI-H460 lung cancer cells. 7β-OHC decreased clonogenic survival of NCI-H460 in a dose dependent pattern. 7β-OHC induced apoptosis in NCI-H460, with the characteristic features like increase in sub-G_1 hypodiploid (apoptotic) cells, and apoptotic body formation, as evidenced by flow cytometry and fluorescence microscope, respectively. Apoptosis was also associated with loss of mitochondrial transmembrane potential, and the activation of caspases 9 and 3. 7β-OHC resulted in generation of reactive oxygen species (ROS) during apoptosis. On the whole, the results indicated that 7β-OHC inhibited the proliferation of NCI-H460 cells through apoptosis via caspase activation.

• 社団法人日本薬学会の論文
• 2005-08-01

著者

• Lee Y

  Laboratory Of Radiation Effect Korea Cancer Center Hospital

• Lee Su

  Laboratory Of Radiation Effect Korea Cancer Center Hospital

• Lee Kyoung

  Department Of Biochemistry College Of Medicine And Applied Radiological Science Research Institute C

• Kang Kyoung

  School Of Medicine And Applied Radiological Science Research Institute Cheju National University

• KANG Kyoung

  Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute,

• HYUN Jin

  Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute,

• CHAE Sungwook

  Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute,

• PARK Moon

  Laboratory of Radiation Effect, Korea Cancer Center Hospital

• LEE Yun

  Laboratory of Radiation Effect, Korea Cancer Center Hospital

• Hyun Jin

  School Of Medicine And Applied Radiological Science Research Institute Cheju National University

• Lee Youngki

  Laboratory Of Radiation Effect Korea Cancer Center Hospital

• Chae Sungwook

  Department Of Biochemistry College Of Medicine And Applied Radiological Science Research Institute C

• Chae S

  Department Of Biochemistry College Of Medicine And Applied Radiological Science Research Institute C

• Lee Yun

  Laboratory Of Dermato-immunology Catholic Research Institute Of Medical Science College Of Medicine

• Hyun Jin

  Department Of Biochemistry College Of Medicine Cheju National University

• Park Moon

  Laboratory Of Radiation Effect Korea Cancer Center Hospital

• KANG Kyoung

  College of Medicine, Jeju National University

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