Anti-complementary Activity of Ursane-Type Triterpenoids from Weigela subsessilis(Pharmacognosy)
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概要
- 論文の詳細を見る
A new ursane-type triterpenoid, weigelic acid (1), and seven known compounds, ursolic acid (2), ilekudinol A (3), corosolic acid (4), ilekudinol B (5), esculentic acid (6), pomolic acid (7), and asiatic acid (8) were isolated from the leaf and stem of Weigela subsessilis. The structure of the new triterpenoid was established as 1β, 2α, 3α, 23-tetrahydroxyurs-12-en-28-oic acid on the basis of spectroscopic analyses. In addition, the isolated compounds were evaluated for their anti-complement activity against the classical pathway of the complement system. Of these, compounds 1-2 and 4-8 exhibited anti-complement activity with IC_<50> values of 152, 90, 130, 51, 56, 4, and 163μM, respectively, whereas 3 was inactive. This shows that a carboxylic group of ursane-type triterpenoids seems to play an important role in inhibiting the hemolytic activity of human serum against erythrocytes.
- 公益社団法人日本薬学会の論文
- 2006-04-01
著者
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SEONG Yeon
College of Veterinary Medicine, Chungbuk National University
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BAE KiHwan
College of Pharmacy, Chungnam National University
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Song Kyung
College Of Agriculture And Life Science Kyungpook National University
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KANG Sam
Natural Products Institute, Seoul National University
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BAE Ki
College of Pharmacy, Chungnam National University
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Thuong Phuong
Vietnam National Inst. Of Medicinal Materials
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Thuong Phuong
College Of Pharmacy Chungnam National University
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Thuong Phuong
College Of Pharmacy Chosun University
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Bae Ki
College Of Pharmacy Chungnam National University
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Bae Kihwan
韓国
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Lee Hyeong-kyu
韓国
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Lee Hyeong-kyu
Korea Research Institute Of Bioscience And Biotechnology
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Min Byung-sun
Coll. Of Pharmacy Catholic Univ. Of Daegu
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Min Byung
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Seong Rack
Korea Food & Drug Administration
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Kang S‐s
Natural Products Research Institute Seoul National University
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Kang Sam
Natural Product Research Institute Seoul National University
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Min Byung-sun
College Of Pharmacy Catholic University Of Daegu
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Bae Kihwan
College Of Pharmacy Chungnam National University
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Seong Yeon
Coll. Of Veterinary Medicine Chungbuk National Univ. Kor
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LEE JongPill
Korea Food & Drug Administration
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JIN WenYi
College of Pharmacy, Chungnam National University
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Jin Wen
College Of Pharmacy Chungnam National University
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NA MinKyun
Korea Research Institute of Bioscience and Biotechnology
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NA Min
Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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Na Minkyun
Korea Res. Inst. Of Bioscience And Biotechnology (kribb)
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Song Kyung
Coll. Of Agriculture And Life Sci. Kyungpook National Univ.
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Min Byung-sun
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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SEONG RackSeon
Korea Food & Drug Administration
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LEE Young-Mi
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University
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SONG KyungSik
College of Agriculture and Life Science, Kyungbuk National University
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SEONG YeonHee
College of Veterinary Medicine, Chungbuk National University
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Lee Hyeong-kyu
Korea Res. Inst. Of Bioscience And Biotechnology
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Lee Hyeong-kyu
Natural Product Biosynthesis Research Unit Korea Research Institute Of Bioscience & Biotechnolog
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Seong Y
College Of Agriculture And Life Science Kyungpook National University
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Seong Yeonhee
College Of Veterinary Medicine Chungbuk National University
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Min Byung
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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Jin Wenyi
College Of Pharmacy Chungnam National University
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Na Min-kyun
College Of Pharmacy Chungnam National University
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Lee Jong-pill
Korea Food & Drug Administration
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Lee Young-mi
Department Of Nursing Hanbuk University
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Bae K
College Of Pharmacy Chungnam National University
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LEE Young
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University
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