Endothelium-Dependent Vasodilatory and Hypotensive Effects of Crotalaria Sessiliflora L. in Rats(Pharmacology)

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概要

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• The aim of the present study was to investigate the vasoactive effect of Crotalaria sessiliflora L. extract (CSE) on rats and its mechanism when combining in vivo and in vitro approaches. CSE (0.5-5mg/ml) induced concentration-dependent relaxation on endothelium-intact thoracic aortic rings precontracted with phenylephrine (PE, 10^<-5>M). This effect disappeared with the removal of functional endothelium. Pretreatment of the aortic strips with either N^G-nitro-L-arginine (L-NNA, 10^<-5>M) or methylene blue (10^<-5>M) significantly reduced the relaxation induced by CSE. The endothelium-dependent relaxation caused by CSE was associated with production of cGMP. CSE (5mg/ml) increased the production of cGMP in endothelium-intact aortic rings and this effect was significantly attenuated by L-NNA (10^<-5>M) and methylene blue (10^<-5>M). Relaxation in response to CSE in strips precontracted with PGF_<2α> (3×10^<-5>M) was eliminated by removing extracellular Ca^<2+> and significantly reduced by pretreatment with ruthenium red (10^<-5>M). In in vivo tests, injection of 40mg/kg of CSE induced an increase in plasma NO production, and this effect was blocked by L-NNA. Furthermore, CSE produced dose-dependent and transient decrease in blood pressure in normotensive rats and this effect was blocked by atropine as well as L-NNA. These findings suggest that CSE induces endothelium-dependent relaxation via NO/cGMP signaling by promoting extracellular Ca^<2+> influx and the release of Ca^<2+> from intracellular stores of endothelium, probably due to endothelial muscaric receptor activation.

• 公益社団法人日本薬学会の論文
• 2007-01-01

著者

• Kim Tae

  Department Of Materials Science And Engineering Korea Advanced Institute Of Science And Technology

• KOH Sang

  Safety Assessment Center, Korea Testing and Research Institute for Chemical Industry

• SEONG Yeon

  College of Veterinary Medicine, Chungbuk National University

• Park Hee

  National Research Lab. Of Pharmaceutical Technology College Of Pharmacy Chungnam National University

• Seong Yeon

  College Of Veterinary Medicine And Research Institute Of Herbal Medicine Chungbuk National Universit

• Kang Myung

  Department Of Dermatology Hanyang University College Of Medicine

• Seong Yeon

  College Of Agriculture And Life Science Kyungpook National University

• Kang Myung

  Department Of Food Science And Nutrition Hoseo University

• Kang Myung

  Department Of Chemistry Chung-ang University

• Seong Ha

  Safety Assessment Center Korea Testing And Research Institute For Chemical Industry

• Koh Sang

  Safety Assessment Center Korea Testing And Research Institute For Chemical Industry

• Koh Sang

  Safety Assessment Center Korea Testing And Research Institute For Chemical Industry:college Of Veter

• Kim Tae

  Department Of Anesthesia And Pain Medicine School Of Medicine Pusan National University

• PARK Chun

  National Institute of Crop Science

• Kim Tae

  Department Of Food Science And Nutrition Hoseo University

• Park Hee

  National Institute Of Crop Science

• Kim Tae

  Department of Advanced Materials Engineering, Sungkyunkwan University, Suwon, Gyeonggi 440-746, Republic Korea

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