Effect of Astilbe koreana on Ultraviolet B (UVB)-Induced Inflammatory Response in Human Keratinocytes(Pharmacognosy)
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概要
- 論文の詳細を見る
The EtOH extract from the rhizomes of Astilbe koreana (Saxifragaceae) exhibited potent antioxidant activity in our recent study. Since the oxidative stress is known to be involved in the inflammatory response after ultraviolet B (UVB) exposure, the ability of the A. koreana extract to inhibit UVB-induced prostaglandin E_2 (PGE_2) and nitric oxide (NO) production was examined. UVB irradiation (35 mJ/cm^2) increased PGE_2 and NO production, which were significantly decreased by pre-administration of the A. koreana extract in a dose-dependent manner. The A. koreana extract also preserved cellular antioxidant capacity after UVB irradiation, which was determined by glutathione (GSH) content. UVB irradiation enhanced the formation of ROS in the keratinocytes, which was determined using a 2,7'-dichlorofluorescein diacetate (DCFH-DA), a redox sensitive dye. The levels of intracellular reactive oxygen species (ROS) were also significantly reduced by pre-treatment of the A. koreana extract in a dose-dependent manner measured 9 h after UVB irradiation. The results suggest that the A. koreana extract may have a protective effect on the UVB-injured keratinocytes by inhibiting PGE_2 and NO production, possibly through the inhibition of intracellular ROS accumulation.
- 公益社団法人日本薬学会の論文
- 2004-08-01
著者
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SEONG Yeon
College of Veterinary Medicine, Chungbuk National University
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BAE KiHwan
College of Pharmacy, Chungnam National University
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Song Kyung
College Of Agriculture And Life Science Kyungpook National University
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BAE Ki
College of Pharmacy, Chungnam National University
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Bae Ki
College Of Pharmacy Chungnam National University
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Bae Kihwan
韓国
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An Ren-bo
韓国
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An Ren-bo
Key Lab. Of Organism Functional Factors Of The Changbai Mountain Coll. Of Pharmacy Yanbian Univ.
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An Ren-bo
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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An Ren
韓国
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An Ren
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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An Ren-bo
College Of Pharmacy Chungnam National University
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Min Byung-sun
Coll. Of Pharmacy Catholic Univ. Of Daegu
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Min Byung
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Na MinKyun
College of Pharmacy, Yeungnam University
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Bae Kihwan
College Of Pharmacy Chungnam National University
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Seong Yeon
Coll. Of Veterinary Medicine Chungbuk National Univ. Kor
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NA Min
Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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Na Minkyun
Korea Res. Inst. Of Bioscience And Biotechnology (kribb)
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Na Minkyun
College Of Pharmacy Chungnam National University
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MIN Byung
Laboratory of Immunomodulator, Korea Research Institute of Bioscience & Biotechnology
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Song Kyung
Coll. Of Agriculture And Life Sci. Kyungpook National Univ.
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Min Byung-sun
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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SONG Kyung
Division of Applied Biology and Chemistry, College of Agriculture and Life Science, Kyungpook Nation
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Seong Y
College Of Agriculture And Life Science Kyungpook National University
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Seong Yeon
College Of Agriculture And Life Science Kyungpook National University
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Min Byung
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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Na Min-kyun
College Of Pharmacy Chungnam National University
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Bae K
College Of Pharmacy Chungnam National University
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